PDF(Pubmed)
Abstract：
Tick-borne encephalitis (TBE) is an acute disease caused by the tick-borne encephalitis virus. Due to the viral nature of the condition, there is no effective causal treatment for full-blown disease. Current and nonspecific TBE treatments only relieve symptoms. Unfortunately, the first phase of TBE is characterized by flu-like symptoms, making diagnosis difficult during this period. The second phase is referred to as the neurological phase as it involves structures in the central nervous system-most commonly the meninges and, in more severe cases, the brain and the spinal cord. Therefore, it is important that early markers of TBE that will guide clinical decision-making and the choice of treatment are established. In this review, we performed an extensive search of literature reports relevant to biomarkers associated with TBE using the MEDLINE/PubMed database. We observed that apart from routinely determined specific immunoglobulins, free light chains may also be useful in the evaluation of intrathecal synthesis in the central nervous system (CNS) during TBEV infection. Moreover, selected metalloproteinases, chemokines, or cytokines appear to play an important role in the pathogenesis of TBE as a consequence of inflammatory reactions and recruitment of white blood cells into the CNS. Furthermore, we reported promising findings on tau protein or Toll-like receptors. It was also observed that some people may be predisposed to TBE. Therefore, to understand the role of selected tick-borne encephalitis biomarkers, we categorized these factors and discussed their potential application in the diagnosis, prognosis, monitoring, or management of TBE.
摘要：
蜱传脑炎（TBE）是由蜱传脑炎病毒引起的急性疾病。由于病情的病毒性，对于全面发展的疾病，没有有效的因果治疗方法。目前的和非特异性的TBE治疗只能缓解症状。不幸的是,TBE的第一阶段以流感样症状为特征，在这段时间内诊断困难。第二阶段被称为神经阶段，因为它涉及中枢神经系统的结构-最常见的是脑膜，在更严重的情况下，大脑和脊髓.因此,建立指导临床决策和治疗选择的TBE早期标志物非常重要.在这次审查中,我们使用MEDLINE/PubMed数据库广泛检索了与TBE相关的生物标志物相关的文献报告.我们观察到，除了常规确定的特异性免疫球蛋白，游离轻链也可用于评估TBEV感染期间中枢神经系统（CNS）的鞘内合成。此外，选定的金属蛋白酶，趋化因子,或细胞因子似乎在TBE的发病机理中起重要作用，这是炎症反应和白细胞募集到CNS的结果。此外，我们报道了关于tau蛋白或Toll样受体的有希望的发现.还观察到一些人可能倾向于TBE。因此,为了了解选定的蜱传脑炎生物标志物的作用，我们对这些因素进行了分类，并讨论了它们在诊断中的潜在应用，预后,监测,或TBE的管理。
