Abstract：
Purpose: To describe and illustrate recent reclassification and clinical descriptions of the histiocytoses, diagnosis and management, and effects on the eye and adnexaePatients and methods: Literature review with an illustrative case series of seven patients with histiocytosis and ophthalmic involvement from a single tertiary centre.Results: Skin lesions with signs including eyelid mass, orbital bone destruction, bizarre keratic precipitates, limbal or iris mass, haemorrhagic anterior uveitis, subretinal lesions of uncertain etiology, ischaemic retinopathy, optic neuropathy, and apparent steroid-resistant inflammations should be comprehensively investigated.Conclusions: Ophthalmic involvement in histiocytosis is rare. Clinical manifestations vary from limited single-organ disease to lethal systemic infiltration or malignancy. Radiology may identify lesions for biopsy. Histology with appropriate markers is essential. Oncology advice may be required.
摘要：
目的：描述和说明最近对组织细胞病的重新分类和临床描述，诊断和管理，对眼睛和附件的影响患者和方法：文献回顾了一个说明性的病例系列，该病例系列包括来自单个三级中心的7例组织细胞增生症和眼科受累患者。结果：皮肤病变的体征包括眼睑肿块，眶骨破坏,奇异的角化沉淀物，角膜缘或虹膜肿块，出血性前葡萄膜炎,病因不明的视网膜下病变，缺血性视网膜病变,视神经病变,应全面调查明显的类固醇抗性炎症。结论：组织细胞增生症的眼科受累很少。临床表现从有限的单器官疾病到致命的全身性浸润或恶性肿瘤。放射学可以识别活检的病变。具有适当标记的组织学是必不可少的。可能需要肿瘤咨询。
