PDF(Pubmed)
Abstract：
BACKGROUND: Autoimmune diseases refers to a class of diseases involving abnormal immune response of human body and tissue damage caused by the dysregulation of autoimmune balance or destruction of immune tolerance. Recent research has revealed that the occurrence of autoimmune diseases is influenced by genetic, hormonal, immunological, and environmental factors. As sex hormone levels change obviously during pregnancy and postpartum, the morbidity and recurrence rate of autoimmune diseases increase during this period.
METHODS: A 31-year-old Asian woman was admitted to our hospital for myasthenia gravis and treated with methylprednisolone and pyridostigmine bromide 3 months postpartum. Physical examination and laboratory inspection after admission suggested that the patient had primary biliary cirrhosis. Subsequently, azathioprine was added to the treatment, and the symptoms of both diseases were successfully controlled.
CONCLUSIONS: This case exhibits a rare condition of myasthenia gravis combined with primary biliary cirrhosis postpartum. Given the fluctuation of the immune status during the postpartum period, combined autoimmune diseases need to be taken into account when patients develop clinical symptoms of an autoimmune disease. Therefore, detailed physical and laboratory examination can help to prevent the missed diagnosis of these diseases.
METHODS: A 31-year-old Asian woman was admitted to our hospital for myasthenia gravis and treated with methylprednisolone and pyridostigmine bromide 3 months postpartum. Physical examination and laboratory inspection after admission suggested that the patient had primary biliary cirrhosis. Subsequently, azathioprine was added to the treatment, and the symptoms of both diseases were successfully controlled.
CONCLUSIONS: This case exhibits a rare condition of myasthenia gravis combined with primary biliary cirrhosis postpartum. Given the fluctuation of the immune status during the postpartum period, combined autoimmune diseases need to be taken into account when patients develop clinical symptoms of an autoimmune disease. Therefore, detailed physical and laboratory examination can help to prevent the missed diagnosis of these diseases.
摘要：
背景：自身免疫性疾病是指由于自身免疫平衡失调或免疫耐受破坏而引起的人体异常免疫应答和组织损伤的一类疾病。最近的研究表明,自身免疫性疾病的发生受遗传因素的影响,荷尔蒙，免疫学，和环境因素。由于性激素水平在怀孕和产后发生明显变化，在此期间，自身免疫性疾病的发病率和复发率增加。
方法：一名31岁亚裔妇女因重症肌无力入院，产后3个月接受甲基强的松龙和溴化吡啶斯的明治疗。入院后体格检查和实验室检查提示患者患有原发性胆汁性肝硬化。随后，硫唑嘌呤被添加到治疗中，两种疾病的症状都得到了成功控制。
结论：该病例表现为产后重症肌无力合并原发性胆汁性肝硬化的罕见病症。鉴于产后免疫状态的波动，当患者出现自身免疫性疾病的临床症状时，需要考虑合并的自身免疫性疾病。因此,详细的物理和实验室检查有助于防止这些疾病的漏诊。
方法：一名31岁亚裔妇女因重症肌无力入院，产后3个月接受甲基强的松龙和溴化吡啶斯的明治疗。入院后体格检查和实验室检查提示患者患有原发性胆汁性肝硬化。随后，硫唑嘌呤被添加到治疗中，两种疾病的症状都得到了成功控制。
结论：该病例表现为产后重症肌无力合并原发性胆汁性肝硬化的罕见病症。鉴于产后免疫状态的波动，当患者出现自身免疫性疾病的临床症状时，需要考虑合并的自身免疫性疾病。因此,详细的物理和实验室检查有助于防止这些疾病的漏诊。
