Abstract：
People with substance use disorders (SUDs) usually experience emotion dysregulation, which may be a consequence of or a risk factor for the development and maintenance of substance misuse. Despite growing evidence on emotion dysregulation among people with SUDs, relatively few studies have explored emotion dysregulation in heroin use disorder (HUD) patients.
Using event-related potentials (ERP), we compared the emotion regulation ability of 33 HUD patients and 30 healthy controls according to their average electroencephalogram amplitudes of the late positive potential (LPP) component in 400-1000 ms and 1000-2000 ms time windows, while viewing neutral and unpleasant emotional pictures, and using emotion regulation strategies (expressive suppression, cognitive reappraisal, and a combination) while viewing unpleasant pictures. We recorded their mood states and how successfully they used emotion regulation strategies in each block using 7-point scales.
Relative to healthy controls, the LPP amplitudes of HUD patients were significantly lower when viewing emotional stimuli (pearlyLPP < 0.05) and using emotion regulation strategies (all p < 0.05). The left hemisphere was more active in healthy controls (pearlyLPP < 0.05, plateLPP < 0.01); there were no differences in scalp position activation among HUD patients.
Compared to healthy controls, HUD patients\' emotional arousal and emotion regulation ability were impaired, as reflected by the LPP component. Their abnormal scalp activation pattern may imply abnormal brain activity. Future research could explore this with electroencephalogram source analysis techniques, functional magnetic resonance imaging, or other technologies. Intervention effects for emotion dysregulation in HUD treatment are also worth exploring.
Using event-related potentials (ERP), we compared the emotion regulation ability of 33 HUD patients and 30 healthy controls according to their average electroencephalogram amplitudes of the late positive potential (LPP) component in 400-1000 ms and 1000-2000 ms time windows, while viewing neutral and unpleasant emotional pictures, and using emotion regulation strategies (expressive suppression, cognitive reappraisal, and a combination) while viewing unpleasant pictures. We recorded their mood states and how successfully they used emotion regulation strategies in each block using 7-point scales.
Relative to healthy controls, the LPP amplitudes of HUD patients were significantly lower when viewing emotional stimuli (pearlyLPP < 0.05) and using emotion regulation strategies (all p < 0.05). The left hemisphere was more active in healthy controls (pearlyLPP < 0.05, plateLPP < 0.01); there were no differences in scalp position activation among HUD patients.
Compared to healthy controls, HUD patients\' emotional arousal and emotion regulation ability were impaired, as reflected by the LPP component. Their abnormal scalp activation pattern may imply abnormal brain activity. Future research could explore this with electroencephalogram source analysis techniques, functional magnetic resonance imaging, or other technologies. Intervention effects for emotion dysregulation in HUD treatment are also worth exploring.
摘要：
患有物质使用障碍（SUDs）的人通常会经历情绪失调，这可能是药物滥用发展和维持的后果或风险因素。尽管越来越多的证据表明SUD患者情绪失调，很少有研究探讨海洛因使用障碍（HUD）患者的情绪失调。
使用事件相关电位(ERP)，我们比较了33名HUD患者和30名健康对照者的情绪调节能力，根据他们在400-1000ms和1000-2000ms时间窗口中晚期正电位（LPP）分量的平均脑电图幅度，在观看中性和不愉快的情感图片时，并使用情绪调节策略(表达抑制，认知重估，和组合），同时观看令人不快的图片。我们使用7点量表记录了他们的情绪状态以及他们在每个块中使用情绪调节策略的成功程度。
相对于健康对照，当观察情绪刺激（pearlyLPP<0.05）和使用情绪调节策略（所有p<0.05）时，HUD患者的LPP振幅显着降低。在健康对照组中，左半球更活跃（pearlyLPP<0.05，plateLPP<0.01）；HUD患者的头皮位置激活没有差异。
与健康对照相比，HUD患者的情绪唤醒和情绪调节能力受损，如LPP组件所反映的。他们的异常头皮激活模式可能意味着大脑活动异常。未来的研究可以通过脑电图源分析技术来探索这一点，功能磁共振成像，或其他技术。在HUD治疗中对情绪失调的干预作用也值得探讨。
使用事件相关电位(ERP)，我们比较了33名HUD患者和30名健康对照者的情绪调节能力，根据他们在400-1000ms和1000-2000ms时间窗口中晚期正电位（LPP）分量的平均脑电图幅度，在观看中性和不愉快的情感图片时，并使用情绪调节策略(表达抑制，认知重估，和组合），同时观看令人不快的图片。我们使用7点量表记录了他们的情绪状态以及他们在每个块中使用情绪调节策略的成功程度。
相对于健康对照，当观察情绪刺激（pearlyLPP<0.05）和使用情绪调节策略（所有p<0.05）时，HUD患者的LPP振幅显着降低。在健康对照组中，左半球更活跃（pearlyLPP<0.05，plateLPP<0.01）；HUD患者的头皮位置激活没有差异。
与健康对照相比，HUD患者的情绪唤醒和情绪调节能力受损，如LPP组件所反映的。他们的异常头皮激活模式可能意味着大脑活动异常。未来的研究可以通过脑电图源分析技术来探索这一点，功能磁共振成像，或其他技术。在HUD治疗中对情绪失调的干预作用也值得探讨。
