关键词： ADAMs, adisintegrin and metalloproteases AJ, adherens junctions Antagonists CAFs, cancer-associated fibroblasts CAR, chimeric antigen receptor CRC, colorectal cancer CSC, cancer stem cell Clinical trial ECM, extracellular matrix EGFR, epidermal growth factor receptor EMT, epithelial–mesenchymal transition ERK, extracellular regulated kinase Extracellular matrix FAK, focal adhesion kinase FDA, U.S. Food and Drug Administration HIF-1α, hypoxia-inducible factor-1α HUVECs, human umbilical vein endothelial cells ICAMs, intercellular adhesion molecules IGFR, insulin-like growth factor receptor IMD, integrin-mediated death Integrins JNK, c-Jun N-terminal kinase 16 MAPK, mitogen-activated protein kinase MMP2, matrix metalloprotease 2 NF-κB, nuclear factor-κB NSCLC, non-small cell lung cancer PDGFR, platelet-derived growth factor receptor PI3K, phosphatidylinositol 3-kinase RGD, Arg-Gly-Asp RTKs, receptor tyrosine kinases SAPKs, stress-activated MAP kinases SDF-1, stromal cell-derived factor-1 SH2, Src homology 2 STAT3, signal transducer and activator of transcription 3 TCGA, The Cancer Genome Atlas TICs, tumor initiating cells TNF, tumor necrosis factor Targeted drug Tumor progression VCAMs, vascular cell adhesion molecules VEGFR, vascular endothelial growth factor receptor mAb, monoclonal antibodies sdCAR-T, switchable dual-receptor CAR-engineered T siRNA, small interference RNA uPA, urokinase-type plasminogen activator

来  源：   DOI：10.1016/j.apsb.2021.01.004   PDF(Sci-hub)   PDF(Pubmed)

Abstract：
Integrins are transmembrane receptors that have been implicated in the biology of various human physiological and pathological processes. These molecules facilitate cell-extracellular matrix and cell-cell interactions, and they have been implicated in fibrosis, inflammation, thrombosis, and tumor metastasis. The role of integrins in tumor progression makes them promising targets for cancer treatment, and certain integrin antagonists, such as antibodies and synthetic peptides, have been effectively utilized in the clinic for cancer therapy. Here, we discuss the evidence and knowledge on the contribution of integrins to cancer biology. Furthermore, we summarize the clinical attempts targeting this family in anti-cancer therapy development.
摘要：
整合素是跨膜受体,其已经涉及各种人类生理和病理过程的生物学。这些分子促进细胞-细胞外基质和细胞-细胞相互作用，它们与纤维化有关，炎症,血栓形成,和肿瘤转移。整合素在肿瘤进展中的作用使它们成为癌症治疗的有希望的靶标，和某些整合素拮抗剂，如抗体和合成肽，已在临床上有效地用于癌症治疗。这里,我们讨论了关于整合素对癌症生物学的贡献的证据和知识。此外，我们总结了在抗癌治疗开发中针对该家族的临床尝试。
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