Nocardia farcinica Brain Abscess in a Multiple Myeloma Patient Treated with Proteasome Inhibitor: A Case Report and Review of the Literature.

• 影响指数: 3.333
• 发表时间: Sep 2021 13
• 来源期刊: Brain Sci
• DOI: 10.3390/brainsci11091204
• PMID: 34573225
• 文章类型: Case Reports
• 作者列表: Xu N,Li L,Lei W,Qian W

关键词: Nocardia farcinica; brain abscess; multiple myeloma; proteasome inhibitor

Abstract

Nocardia brain abscess is relatively rare, accounting for about 1-2% of all brain abscesses, and its mortality rate is three times higher than of other types of bacterial brain abscesses; thus, early diagnosis and treatment are essential. Nocardia brain abscess generally occurs in immunodeficient patients. We report a case of Nocardia farcinica brain abscess in a multiple myeloma patient treated with proteasome inhibitor (bortezomib and ixazomib), cyclophosphamide, and corticosteroid. The patient was treated with ceftriaxone and trimethoprim-sulfamethoxazole, together with drainage of the brain abscess. Regular brain MRI follow-ups showed that intracranial lesions were gradually absorbed and improved.