PDF(Pubmed)
Abstract：
Plaque psoriasis is a common inflammatory condition of the skin characterized by red, flaking lesions. Current therapies for plaque psoriasis target many facets of the autoimmune response, but there is an incomplete understanding of how oxidative damage produced by enzymes such as myeloperoxidase contributes to skin pathology. In this study, we used the Aldara (Imiquimod) cream model of plaque psoriasis in mice to assess myeloperoxidase inhibition for treating psoriatic skin lesions. To assess skin inflammation severity, an innovative mouse psoriasis scoring system was developed. We found that myeloperoxidase inhibition ameliorated psoriasis severity when administered either systemically or topically. The findings of this study support the role of oxidative damage in plaque psoriasis pathology and present potential new therapeutic avenues for further exploration.
摘要：
斑块型牛皮癣是一种常见的皮肤炎症，其特征是红色，剥落的损伤。目前治疗斑块状银屑病的目标是自身免疫反应的许多方面，但是对髓过氧化物酶等酶产生的氧化损伤如何导致皮肤病理的理解还不完全。在这项研究中,我们使用Aldara(Imiquimod)乳膏治疗小鼠斑块状银屑病模型来评估髓过氧化物酶抑制治疗银屑病皮损。为了评估皮肤炎症的严重程度，开发了一种创新的小鼠牛皮癣评分系统。我们发现，全身或局部给药时，髓过氧化物酶的抑制作用可改善牛皮癣的严重程度。这项研究的发现支持了氧化损伤在斑块状银屑病病理中的作用，并为进一步探索提供了潜在的新的治疗途径。
