PDF(Pubmed)
Abstract：
Eukaryotic messenger mRNAs contain many RNA methyl chemical modifications, in which N6-methyladenosine (m6A) plays a very important role. The modification process of RNA methylation is a dynamic reversible regulatory process that is mainly catalyzed by \"Writer\" m6A methyltransferase, removed by \"Eraser\" m6A demethylase, and recognized by the m6A binding protein, thereby, linking m6A modification with other mRNA pathways. At various stages of the life cycle, m6A modification plays an extremely important role in regulating mRNA splicing, processing, translation, as well as degradation, and is associated with gametogenesis and fertility for both sexes. Normal gametogenesis is a basic guarantee of fertility. Infertility leads to trauma, affects harmony in the family and seriously affects the quality of life. We review the roles and mechanisms of RNA m6A methylation modification in infertility and provide a potential target for infertility treatment, which can be used for drug development.
摘要：
真核信使mRNA含有许多RNA甲基化学修饰，其中N6-甲基腺苷（m6A）起着非常重要的作用。RNA甲基化的修饰过程是一个动态可逆的调控过程，主要由\"Writer\"m6A甲基转移酶催化，被“橡皮擦”M6A去甲基酶移除，并被m6A结合蛋白识别，因此，连接m6A修饰与其他mRNA途径。在生命周期的各个阶段，m6A修饰在调节mRNA剪接中起着极其重要的作用,processing,翻译,以及退化，并且与两性的配子发生和生育能力有关。正常的配子发生是生育能力的基本保证。不孕导致创伤,影响家庭和谐,严重影响生活质量。我们综述了RNAm6A甲基化修饰在不孕症中的作用和机制，并为不孕症的治疗提供一个潜在的靶点。可用于药物开发。
