Abstract：
The nuclear envelope (NE) is a protective barrier to the genome, yet its membranes undergo highly dynamic remodeling processes that are necessary for cell growth and maintenance. While mechanisms by which proteins promote NE remodeling are emerging, the types of bilayer lipids and the lipid-protein interactions that define and sculpt nuclear membranes remain elusive. The NE is continuous with the endoplasmic reticulum (ER) and recent evidence suggests that lipids produced in the ER are harnessed to remodel nuclear membranes. In this review, we examine new roles for lipid species made proximally within the ER and locally at the NE to control NE dynamics. We further explore how the biosynthesis of lipids coordinates NE remodeling to ensure genome protection.
摘要：
核膜（NE）是基因组的保护性屏障，然而，它的膜经历了高度动态的重塑过程，这是细胞生长和维持所必需的。虽然蛋白质促进NE重塑的机制正在出现，定义和雕刻核膜的双层脂质类型和脂质-蛋白质相互作用仍然难以捉摸。NE与内质网（ER）连续，最近的证据表明，ER中产生的脂质可用于重塑核膜。在这次审查中,我们研究了在ER附近和NE局部产生的脂质种类的新作用，以控制NE动力学。我们进一步探索脂质的生物合成如何协调NE重塑以确保基因组保护。
