Abstract：
BACKGROUND: Dissecting cellulitis of the scalp (DCS) is a rare but distinctive, chronic suppurative condition, and the treatment is a therapeutic challenge. Recently, treatment of DCS with 5-aminolaevulinic acid photodynamic therapy (ALA-PDT) has been considered as a potential option.
OBJECTIVE: To evaluate the efficacy and safety of 20% ALA-PDT pretreated by fire needle in the treatment of DCS.
METHODS: Topical 20% ALA-PDT with fire needle intervention as a pretreatment, was applied to six patients with DCS. All patients completed three sessions treatment at an interval of ten days. They were assessed for the efficacy at the baseline and on ten days after each treatment. According to the reduction of lesions and the improvements of patients\' symptoms after each session, the objective assessment of therapeutic effect was divided into four grades. The adverse effects were recorded.
RESULTS: A total of six male patients were enrolled in our study. After three sessions of ALA-PDT, among them, three patients recovered, two patients achieved significant improvement and one patient achieved partial response.Patient 4 (Pt.4) relapsed at 6-month follow-up. Pt.1 and Pt.6. maintained complete response after one year follow-up. We also found that the clearance rate of the popular/nodular and cyst/abscess was much higher than sinus.
CONCLUSIONS: 20% ALA-PDT pretreated by fire needle could be an effective, minimally-invasive, safe method for DCS patients. Lesion in the early stages have a better response than sinus.
OBJECTIVE: To evaluate the efficacy and safety of 20% ALA-PDT pretreated by fire needle in the treatment of DCS.
METHODS: Topical 20% ALA-PDT with fire needle intervention as a pretreatment, was applied to six patients with DCS. All patients completed three sessions treatment at an interval of ten days. They were assessed for the efficacy at the baseline and on ten days after each treatment. According to the reduction of lesions and the improvements of patients\' symptoms after each session, the objective assessment of therapeutic effect was divided into four grades. The adverse effects were recorded.
RESULTS: A total of six male patients were enrolled in our study. After three sessions of ALA-PDT, among them, three patients recovered, two patients achieved significant improvement and one patient achieved partial response.Patient 4 (Pt.4) relapsed at 6-month follow-up. Pt.1 and Pt.6. maintained complete response after one year follow-up. We also found that the clearance rate of the popular/nodular and cyst/abscess was much higher than sinus.
CONCLUSIONS: 20% ALA-PDT pretreated by fire needle could be an effective, minimally-invasive, safe method for DCS patients. Lesion in the early stages have a better response than sinus.
摘要：
背景：解剖头皮蜂窝织炎（DCS）是一种罕见但独特的，慢性化脓性疾病，治疗是一个治疗挑战。最近,用5-氨基酮戊酸光动力疗法（ALA-PDT）治疗DCS已被认为是一种潜在的选择。
目的：评价火针预处理20%ALA-PDT治疗DCS的有效性和安全性。
方法：以火针干预作为预处理的局部20%ALA-PDT，应用于6例DCS患者。所有患者以10天的间隔完成三个疗程的治疗。在基线和每次治疗后10天评估它们的功效。根据病变的减少和每次治疗后患者症状的改善情况，治疗效果的客观评估分为四个等级。记录不良反应。
结果：共有6名男性患者被纳入本研究。在ALA-PDT的三次会议之后，其中,三个病人康复了,两名患者获得了显著改善,一名患者获得了部分缓解.患者4(Pt.4)在6个月随访时复发。Pt.1和Pt.6。1年随访后保持完全反应。我们还发现，通俗/结节和囊肿/脓肿的清除率远高于窦。
结论：火针预处理20％ALA-PDT可能是有效的，微创,DCS患者的安全方法。早期病变比鼻窦有更好的反应。
目的：评价火针预处理20%ALA-PDT治疗DCS的有效性和安全性。
方法：以火针干预作为预处理的局部20%ALA-PDT，应用于6例DCS患者。所有患者以10天的间隔完成三个疗程的治疗。在基线和每次治疗后10天评估它们的功效。根据病变的减少和每次治疗后患者症状的改善情况，治疗效果的客观评估分为四个等级。记录不良反应。
结果：共有6名男性患者被纳入本研究。在ALA-PDT的三次会议之后，其中,三个病人康复了,两名患者获得了显著改善,一名患者获得了部分缓解.患者4(Pt.4)在6个月随访时复发。Pt.1和Pt.6。1年随访后保持完全反应。我们还发现，通俗/结节和囊肿/脓肿的清除率远高于窦。
结论：火针预处理20％ALA-PDT可能是有效的，微创,DCS患者的安全方法。早期病变比鼻窦有更好的反应。
