PDF(Pubmed)
Abstract：
Resveratrol is a polyphenolic stilbene derivative widely present in grapes and red wine. Broadly known for its antioxidant effects, numerous studies have also indicated that it exerts anti-inflammatory and antiaging abilities and a great potential in cancer therapy. Regrettably, the oral administration of resveratrol has pharmacokinetic and physicochemical limitations such as hampering its effects so that effective administration methods are demanding to ensure its efficiency. Thus, the present review explores the published data on the application of resveratrol nanoformulations in cancer therapy, with the use of different types of nanodelivery systems. Mechanisms of action with a potential use in cancer therapy, negative effects, and the influence of resveratrol nanoformulations in different types of cancer are also highlighted. Finally, the toxicological features of nanoresveratrol are also discussed.
摘要：
白藜芦醇是广泛存在于葡萄和红葡萄酒中的多酚二苯乙烯衍生物。以其抗氧化作用而广为人知，大量研究还表明，它具有抗炎和抗衰老的能力，在癌症治疗中具有巨大的潜力。遗憾的是,白藜芦醇的口服给药具有药代动力学和物理化学限制，例如阻碍其作用，因此需要有效的给药方法来确保其效率。因此，本综述探讨了白藜芦醇纳米制剂在癌症治疗中应用的已发表数据，使用不同类型的纳米递送系统。在癌症治疗中具有潜在用途的作用机制，负面影响,白藜芦醇纳米制剂在不同类型癌症中的影响也被强调。最后,还讨论了纳米白藜芦醇的毒理学特征。
