PDF(Pubmed)
Abstract：
UNASSIGNED: The cisterna Intrathecal Drug Delivery system (IDDS) with morphine has proven to be effective in treating refractory cancer pain above the middle thoracic vertebrae level in some countries. However, it has not been fully investigated in others. We designed the current project to investigate the efficacy and safety of cisterna IDDS for pain relief in refractory pain above the middle thoracic vertebrae level in advanced cancer patients.
UNASSIGNED: This study protocol allows for eligible cancer patients to receive the cisterna IDDS operation. Pain intensity (Visual Analogue scale, VAS), quality of life (36-Item Short-Form Health Survey, SF-36), and depression (Self-Rating Depression scale, SDS) are assessed along with side effects in the postoperative follow-up visits. Recent literature suggests a potential role for cisterna IDDS morphine delivery for refractory pain states above the middle thoracic level.
UNASSIGNED: The results of this study may provide further evidence that cisterna IDDS of morphine can serve as an effective and safe pain relief strategy for refractory pain above the middle thoracic vertebrae level in advanced cancer patients.
UNASSIGNED: This study protocol allows for eligible cancer patients to receive the cisterna IDDS operation. Pain intensity (Visual Analogue scale, VAS), quality of life (36-Item Short-Form Health Survey, SF-36), and depression (Self-Rating Depression scale, SDS) are assessed along with side effects in the postoperative follow-up visits. Recent literature suggests a potential role for cisterna IDDS morphine delivery for refractory pain states above the middle thoracic level.
UNASSIGNED: The results of this study may provide further evidence that cisterna IDDS of morphine can serve as an effective and safe pain relief strategy for refractory pain above the middle thoracic vertebrae level in advanced cancer patients.
摘要：
■在一些国家，含吗啡的鞘内给药系统（IDDS）已被证明可有效治疗中胸椎水平以上的难治性癌性疼痛。然而,在其他方面还没有得到充分的调查。我们设计了当前项目，以研究CiternaIDDS在晚期癌症患者中胸椎水平以上的顽固性疼痛中缓解疼痛的有效性和安全性。
■本研究方案允许符合条件的癌症患者接受食池IDDS手术。疼痛强度（视觉模拟评分，VAS),生活质量(36项短期健康调查，SF-36)，和抑郁(抑郁自评量表，在术后随访中评估SDS）以及副作用。最近的文献表明，对于中胸水平以上的难治性疼痛状态，CiternaIDDS吗啡递送具有潜在作用。
■这项研究的结果可能提供进一步的证据，表明吗啡的CiternaIDDS可以作为晚期癌症患者中胸椎水平以上顽固性疼痛的有效和安全的疼痛缓解策略。
■本研究方案允许符合条件的癌症患者接受食池IDDS手术。疼痛强度（视觉模拟评分，VAS),生活质量(36项短期健康调查，SF-36)，和抑郁(抑郁自评量表，在术后随访中评估SDS）以及副作用。最近的文献表明，对于中胸水平以上的难治性疼痛状态，CiternaIDDS吗啡递送具有潜在作用。
■这项研究的结果可能提供进一步的证据，表明吗啡的CiternaIDDS可以作为晚期癌症患者中胸椎水平以上顽固性疼痛的有效和安全的疼痛缓解策略。
