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Abstract：
BACKGROUND: Metabolic syndrome (MetS) occurs in a proportion of overweight and obese children and increases their future risk of serious health complications, even in adolescence and young adulthood. We aimed to explore the role of certain adipokines and inflammatory markers in identifying children with MetS.
METHODS: This study is a secondary analysis of data coming from the Healthy Growth Study, a cross-sectional study conducted with schoolchildren in Greece. The present study included data from a representative sample of 1376 schoolchildren (mean age: 11.19 ± 0.66 years), recruited from 77 primary schools in four large regions in Greece. Anthropometric, clinical and biochemical data were recorded. Children\'s body weight status and the presence of MetS were determined and their correlation with the serum levels of leptin, adiponectin and C-reactive protein (CRP) was explored.
RESULTS: The prevalence of the MetS was 21.7 % and 3.7 % in obese and overweight children, respectively. The balance of adipokines was disturbed in obesity, as the serum level of adiponectin decreased as body weight increased, while the serum level of leptin increased. The serum level of the inflammatory marker CRP increased significantly as body weight increased. Discriminant analysis showed that these factors could distinguish the children with MetS as compared to children with no MetS.
CONCLUSIONS: In the under study Mediterranean childhood population, monitoring of the levels of adipokines and CRP could identify the overweight and obese children with MetS. Appropriate individualized dietary and lifestyle interventions can be applied in these children to prevent health complications associated with MetS.
METHODS: This study is a secondary analysis of data coming from the Healthy Growth Study, a cross-sectional study conducted with schoolchildren in Greece. The present study included data from a representative sample of 1376 schoolchildren (mean age: 11.19 ± 0.66 years), recruited from 77 primary schools in four large regions in Greece. Anthropometric, clinical and biochemical data were recorded. Children\'s body weight status and the presence of MetS were determined and their correlation with the serum levels of leptin, adiponectin and C-reactive protein (CRP) was explored.
RESULTS: The prevalence of the MetS was 21.7 % and 3.7 % in obese and overweight children, respectively. The balance of adipokines was disturbed in obesity, as the serum level of adiponectin decreased as body weight increased, while the serum level of leptin increased. The serum level of the inflammatory marker CRP increased significantly as body weight increased. Discriminant analysis showed that these factors could distinguish the children with MetS as compared to children with no MetS.
CONCLUSIONS: In the under study Mediterranean childhood population, monitoring of the levels of adipokines and CRP could identify the overweight and obese children with MetS. Appropriate individualized dietary and lifestyle interventions can be applied in these children to prevent health complications associated with MetS.
摘要：
■代谢综合征（MetS）发生在一定比例的超重和肥胖儿童中，并增加了他们未来发生严重健康并发症的风险，即使在青春期和年轻的成年。我们旨在探讨某些脂肪因子和炎症标志物在识别MetS儿童中的作用。
■这项研究是对健康增长研究数据的二次分析，一项针对希腊学童的横断面研究。本研究包括来自1376名学童（平均年龄：11.19±0.66岁）的代表性样本的数据，从希腊四个大地区的77所小学招募。人体测量,记录临床和生化数据.确定儿童的体重状态和MetS的存在及其与血清瘦素水平的相关性。研究了脂联素和C反应蛋白（CRP）。
■在肥胖和超重儿童中，MetS的患病率分别为21.7％和3.7％，分别。肥胖时脂肪因子的平衡受到干扰，随着体重的增加，血清脂联素水平下降，而血清瘦素水平升高。随着体重的增加，炎症标志物CRP的血清水平显着增加。判别分析表明，与没有MetS的儿童相比，这些因素可以区分患有MetS的儿童。
■在正在研究的地中海儿童群体中，监测脂肪因子和CRP水平可以识别超重和肥胖的MetS儿童.可以在这些儿童中应用适当的个性化饮食和生活方式干预措施，以预防与MetS相关的健康并发症。
■这项研究是对健康增长研究数据的二次分析，一项针对希腊学童的横断面研究。本研究包括来自1376名学童（平均年龄：11.19±0.66岁）的代表性样本的数据，从希腊四个大地区的77所小学招募。人体测量,记录临床和生化数据.确定儿童的体重状态和MetS的存在及其与血清瘦素水平的相关性。研究了脂联素和C反应蛋白（CRP）。
■在肥胖和超重儿童中，MetS的患病率分别为21.7％和3.7％，分别。肥胖时脂肪因子的平衡受到干扰，随着体重的增加，血清脂联素水平下降，而血清瘦素水平升高。随着体重的增加，炎症标志物CRP的血清水平显着增加。判别分析表明，与没有MetS的儿童相比，这些因素可以区分患有MetS的儿童。
■在正在研究的地中海儿童群体中，监测脂肪因子和CRP水平可以识别超重和肥胖的MetS儿童.可以在这些儿童中应用适当的个性化饮食和生活方式干预措施，以预防与MetS相关的健康并发症。
