PDF(Pubmed)
Abstract：
Dicentric (7;9)(p11-13;p11) is a rare but recurrent abnormality in pediatric and adult precursor B acute lymphoblastic leukemia (B-ALL). The rarity precludes a deep understanding of its biology and associated prognosis. However, recent findings have correlated dic(7;9) and PAX5 mutations, highlighting this cytogenetic event\'s involvement in leukemogenesis and may also shed light on the overall prognosis of dic(7;9) B-ALL.
摘要：
Dicentric（7;9）（p11-13；p11）是小儿和成人前体B急性淋巴细胞白血病（B-ALL）中罕见但反复发作的异常。这种稀有性妨碍了对其生物学和相关预后的深刻理解。然而,最近的发现与dic(7;9)和PAX5突变相关，强调此细胞遗传学事件与白血病发生有关，也可能阐明dic（7;9）B-ALL的总体预后。
