PDF(Pubmed)
Abstract：
Acinetobacter species, particularly Acinetobacter baumannii, is the first pathogen on the critical priority list of pathogens for novel antibiotics to become a \"red-alert\" human pathogen. Acinetobacter baumannii is an emerging global antibiotic-resistant gram-negative bacteria that most typically causes biofilm-associated infections such as ventilator-associated pneumonia and catheter-related infection, both of which are resistant to antibiotic therapy. A. baumannii\'s capacity to develop antibiotic resistance mechanisms allows the organism to thrive in hospital settings, facilitating the global spread of multidrug-resistant strains. Although Acinetobacter infections are quickly expanding throughout hospital environments around the world, the highest concentration of infections occurs in intensive care units (ICUs). Biofilms are populations of bacteria on biotic or abiotic surfaces that are encased in the extracellular matrix and play a crucial role in pathogenesis, making treatment options more difficult. Even though a variety of biological and environmental elements are involved in the production of A. baumannii biofilms, glucose is the most important component. Biofilm-mediated A. baumannii infections are the most common type of A. baumannii infection associated with medical equipment, and they are extremely difficult to treat. As a result, health care workers (HCWs) should focus on infection prevention and safety actions to avoid A. baumannii biofilm-related infections caused by medical devices, and they should be very selective when using treatments in combination with anti-biofilms. Therefore, this review discusses biofilm formation in A. baumannii, its role in disease pathogenesis, and its antimicrobial resistance mechanism.
摘要：
不动杆菌属,特别是鲍曼不动杆菌，是新型抗生素成为“红色警报”人类病原体的关键优先病原体清单上的第一个病原体。鲍曼不动杆菌是一种新兴的全球抗生素耐药革兰阴性菌，最常见的是引起生物膜相关感染，如呼吸机相关肺炎和导管相关感染。两者都对抗生素治疗有抗药性。鲍曼不动杆菌发展抗生素耐药机制的能力使生物体在医院环境中茁壮成长，促进多重耐药菌株的全球传播。尽管不动杆菌感染在世界各地的医院环境中迅速扩大，感染浓度最高的是重症监护病房(ICU).生物膜是生物或非生物表面上的细菌种群，被包裹在细胞外基质中，在发病机理中起着至关重要的作用。使治疗选择更加困难。尽管鲍曼不动杆菌生物膜的生产涉及多种生物和环境因素，葡萄糖是最重要的成分。生物膜介导的鲍曼不动杆菌感染是与医疗设备相关的最常见的鲍曼不动杆菌感染类型。而且很难治疗.因此,卫生保健工作者（HCWs）应专注于感染预防和安全行动，以避免由医疗器械引起的鲍曼不动杆菌生物膜相关感染，当与抗生物膜结合使用治疗时，它们应该非常有选择性。因此,这篇综述讨论了鲍曼不动杆菌生物膜的形成，它在疾病发病机理中的作用，及其耐药机制。
