Abstract：
The increase in blood pressure (BP) during somatic growth might have direct determinants but also mediating factors. We investigated whether uric acid (UA) and other metabolic factors would mediate the association between body composition components and BP. A cross-sectional study was conducted in 928 children and adolescents (aged 6-18 years), in which body composition and blood biochemistry were evaluated. Structural equation modeling was performed to test the direct and indirect pathways between systolic blood pressure (SBP) and body composition parameters. Muscle mass (MM) showed a strong direct effect on BP, regardless of sex. In girls, a mediating pathway through UA was not significant, but the association between fat mass (FM) and MM with SBP was mediated by the cluster of metabolic factors. In boys, both MM and FM were associated with SBP through a mediating pathway via UA, but not via the cluster of metabolic factors. The association between body composition and BP in children and adolescents has a complex design and also has a sex-specific mediating component. The increase in the UA levels may affect BP levels early in boys. Also, metabolic changes elicited by FM contribute to the increase in BP at an early age in girls. Novelty: MM showed a strong direct effect on BP, regardless of sex. In girls, the association between FM and MM with SBP was mediated by the cluster of metabolic factors. In boys, both MM and FM were associated with SBP through a mediating pathway via UA.
摘要：
躯体生长过程中血压（BP）的升高可能有直接的决定因素，但也有中介因素。我们调查了尿酸（UA）和其他代谢因素是否会介导身体成分与BP之间的关联。在928名儿童和青少年（6-18岁）中进行了一项横断面研究，其中评估了身体成分和血液生化。进行结构方程模型以测试收缩压（SBP）与身体成分参数之间的直接和间接途径。肌肉质量（MM）对血压有很强的直接影响，不管性别。在女孩中，通过UA的介导途径并不显著，但是脂肪量（FM）和MM与SBP之间的关联是由代谢因子簇介导的。在男孩中，MM和FM均通过UA介导途径与SBP相关，但不是通过代谢因子的集群。儿童和青少年的身体成分与BP之间的关联具有复杂的设计，并且还具有性别特异性的中介成分。UA水平的升高可能会影响男孩早期的BP水平。此外，FM引起的代谢变化有助于女孩早年血压的增加。新颖性：MM对血压有很强的直接影响，不管性别。在女孩中，FM和MM与SBP之间的关联是由代谢因子簇介导的。在男孩中，MM和FM均通过UA介导途径与SBP相关.
