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Abstract：
Coronary heart disease (CHD) is the leading cause of human death worldwide. Genetic factors play an important role in the occurrence of CHD. Our study is designed to investigate the influence of CYP7B1 polymorphisms on CHD risk.
In this case-control study, 508 CHD patients and 510 healthy individuals were recruited to determine the correlation between CYP7B1 polymorphisms (rs7836768, rs6472155, and rs2980003) and CHD risk. The associations were evaluated by computing odds ratios (OR) and 95% confidence intervals (CI) with logistic regression analysis. The association between SNP-SNP interaction and CHD susceptibility was carried out by multifactor dimensionality reduction analyses.
Our study found that rs6472155 is significantly associated with an increased risk of CHD in age > 60 years (OR 2.20, 95% CI = 1.07-4.49, p = 0.031), women (OR 3.17, 95% CI = 1.19-8.44, p = 0.021), and non-smokers (3.43, 95% CI = 1.16-10.09, p = 0.025). Rs2980003 polymorphism has a lower risk of CHD in drinkers (OR 0.47, 95% CI = 0.24-0.91, p = 0.025). Further analyses based on false-positive report probability validated these significant results. Besides, it was found that rs6472155 polymorphism was associated with uric acid level (p = 0.034).
Our study indicated that CYP7B1 polymorphisms are related to the risk of CHD, which provides a new perspective for prevent of CHD.
In this case-control study, 508 CHD patients and 510 healthy individuals were recruited to determine the correlation between CYP7B1 polymorphisms (rs7836768, rs6472155, and rs2980003) and CHD risk. The associations were evaluated by computing odds ratios (OR) and 95% confidence intervals (CI) with logistic regression analysis. The association between SNP-SNP interaction and CHD susceptibility was carried out by multifactor dimensionality reduction analyses.
Our study found that rs6472155 is significantly associated with an increased risk of CHD in age > 60 years (OR 2.20, 95% CI = 1.07-4.49, p = 0.031), women (OR 3.17, 95% CI = 1.19-8.44, p = 0.021), and non-smokers (3.43, 95% CI = 1.16-10.09, p = 0.025). Rs2980003 polymorphism has a lower risk of CHD in drinkers (OR 0.47, 95% CI = 0.24-0.91, p = 0.025). Further analyses based on false-positive report probability validated these significant results. Besides, it was found that rs6472155 polymorphism was associated with uric acid level (p = 0.034).
Our study indicated that CYP7B1 polymorphisms are related to the risk of CHD, which provides a new perspective for prevent of CHD.
摘要：
冠心病（CHD）是世界范围内人类死亡的主要原因。遗传因素在CHD的发生中起重要作用。我们的研究旨在研究CYP7B1多态性对CHD风险的影响。
在本病例对照研究中，招募了508例CHD患者和510例健康个体，以确定CYP7B1多态性（rs7836768，rs6472155和rs2980003）与CHD风险之间的相关性。通过逻辑回归分析计算比值比（OR）和95％置信区间（CI）来评估相关性。SNP-SNP相互作用与CHD易感性之间的关联通过多因素降维分析进行。
我们的研究发现rs6472155与年龄>60岁的冠心病风险增加显著相关(OR2.20,95%CI=1.07-4.49,p=0.031),女性（OR3.17，95%CI=1.19-8.44，p=0.021），非吸烟者（3.43，95%CI=1.16-10.09，p=0.025）。Rs2980003多态性在饮酒者中具有较低的CHD风险(OR0.47,95%CI=0.24-0.91,p=0.025)。基于假阳性报告概率的进一步分析验证了这些重要结果。此外,发现rs6472155多态性与尿酸水平相关(p=0.034)。
我们的研究表明，CYP7B1多态性与冠心病的风险有关。为冠心病的防治提供了新的视角。
在本病例对照研究中，招募了508例CHD患者和510例健康个体，以确定CYP7B1多态性（rs7836768，rs6472155和rs2980003）与CHD风险之间的相关性。通过逻辑回归分析计算比值比（OR）和95％置信区间（CI）来评估相关性。SNP-SNP相互作用与CHD易感性之间的关联通过多因素降维分析进行。
我们的研究发现rs6472155与年龄>60岁的冠心病风险增加显著相关(OR2.20,95%CI=1.07-4.49,p=0.031),女性（OR3.17，95%CI=1.19-8.44，p=0.021），非吸烟者（3.43，95%CI=1.16-10.09，p=0.025）。Rs2980003多态性在饮酒者中具有较低的CHD风险(OR0.47,95%CI=0.24-0.91,p=0.025)。基于假阳性报告概率的进一步分析验证了这些重要结果。此外,发现rs6472155多态性与尿酸水平相关(p=0.034)。
我们的研究表明，CYP7B1多态性与冠心病的风险有关。为冠心病的防治提供了新的视角。
