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Abstract：
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiologic agent that causes Coronavirus Disease 2019 (COVID-19) pandemic, is a newly emerging respiratory RNA virus with exceptional transmissibility and pathogenicity. Numerous COVID-19 related studies have been fast-tracked, with the ultimate goal to end the pandemic. Here we review the major stages of SARS-CoV-2 infection cycle in cells, with specific emphasis on essential host factors. Insights into the cell biology of SARS-CoV-2 infection have accelerated the development of host-directed therapeutics, as shown by dozens of clinical trials evaluating COVID-19 treatments using host-targeting compounds.
摘要：
严重急性呼吸系统综合症冠状病毒2（SARS-CoV-2），导致2019年冠状病毒病（COVID-19）大流行的病原体，是一种新兴的呼吸道RNA病毒，具有特殊的传染性和致病性。许多与COVID-19相关的研究已经得到了快速跟踪，最终目标是结束大流行。在这里，我们回顾了细胞中SARS-CoV-2感染周期的主要阶段，特别强调基本的宿主因素。对SARS-CoV-2感染的细胞生物学的见解加速了宿主导向疗法的发展，如数十项评估使用宿主靶向化合物治疗COVID-19的临床试验所示。
