Abstract：
Osteoradionecrosis (ORN) is a serious complication after radiotherapy for head and neck cancer and is a challenging condition for both the therapist and the patient because of its difficult treatment. Different non-invasive approaches have been published for the treatment of low-grade ORN cases without establishing a standard regimen for treatment. Based on the approach of ORN pathogenesis, the so-called radiatio-induced fibroathrophic process (RIF), a new treatment concept with pentoxifylline and tocopherol (PENTO) has been published. The results of PENTO therapy seem promising as a conservative treatment approach for mild ORN or as an alternative when surgical intervention is not possible or desired. The present study summarizes the current state of the literature and shows the effectiveness of PENTO therapy based on a case report.
摘要：
骨坏死（ORN）是头颈部癌症放疗后的严重并发症，由于其治疗困难，对治疗师和患者都是具有挑战性的疾病。已经发表了不同的非侵入性方法来治疗低度ORN病例，而没有建立标准的治疗方案。基于ORN发病机制的方法，所谓的放射性诱导的纤维营养过程（RIF），已经发表了使用己酮可可碱和生育酚（PENTO）的新治疗概念。PENTO治疗的结果似乎有希望作为轻度ORN的保守治疗方法，或者在不可能或不需要手术干预时作为替代方法。本研究总结了文献的现状，并根据一例病例报告显示了PENTO治疗的有效性。
