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Abstract：
In this paper, a novel method for interaction detection is presented to compare the contact dynamics of macrophages in the Drosophila embryo. The study is carried out by a framework called macrosight, which analyses the movement and interaction of migrating macrophages. The framework incorporates a segmentation and tracking algorithm into analysing the motion characteristics of cells after contact. In this particular study, the interactions between cells is characterised in the case of control embryos and Shot mutants, a candidate protein that is hypothesised to regulate contact dynamics between migrating cells. Statistical significance between control and mutant cells was found when comparing the direction of motion after contact in specific conditions. Such discoveries provide insights for future developments in combining biological experiments with computational analysis.
摘要：
在本文中,提出了一种新的相互作用检测方法，以比较果蝇胚胎中巨噬细胞的接触动力学。这项研究是由一个叫做宏观视觉的框架进行的，分析了迁移巨噬细胞的运动和相互作用。该框架结合了分割和跟踪算法来分析接触后细胞的运动特征。在这项特殊的研究中，在对照胚胎和Shot突变体的情况下，细胞之间的相互作用具有特征，一种候选蛋白，被假设为调节迁移细胞之间的接触动力学。当比较在特定条件下接触后的运动方向时,发现对照和突变细胞之间的统计显著性。这些发现为将生物实验与计算分析相结合的未来发展提供了见解。
