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Abstract：
The cell-cell and cell-ECM junctions within the epithelial tissues are crucial anchoring structures that provide architectural stability, mechanical resistance, and permeability control. Their indispensable role as signaling hubs orchestrating cell shape-related changes such as proliferation, differentiation, migration, and apoptosis has also been well recognized. However, growing amount of evidence now suggests that the multitasking nature of epithelial junctions extends well beyond anchorage-dependent or cell shape change-related biological processes. In this review, we discuss the emerging roles of junctional complexes in regulating innate immune defense, stress resistance, and intracellular proteostasis of the epithelial cells, with emphasis on the upstream regulation of epithelial junctions on various aspects of the epithelial barrier.
摘要：
上皮组织内的细胞-细胞和细胞-ECM连接是提供结构稳定性的关键锚定结构。机械阻力,和渗透率控制。它们作为信号中枢不可或缺的作用，协调细胞形状相关的变化，如增殖，分化,迁移,细胞凋亡也得到了很好的认可。然而,现在，越来越多的证据表明，上皮连接的多任务处理性质远远超出了锚定依赖性或细胞形状变化相关的生物过程。在这次审查中,我们讨论了连接复合物在调节先天免疫防御中的新兴作用，抗应力，和上皮细胞的细胞内蛋白稳定，强调上皮连接对上皮屏障各个方面的上游调节。
