PDF(Pubmed)
Abstract：
The purpose of the study was to investigate the bacterial viability of the initial biofilm on the surface of experimental modified dental resin composites. Twenty-five healthy individuals with good oral hygiene were included in this study. In a split-mouth design, they received acrylic splints with five experimental composite resin specimens. Four of them were modified with either a novel polymeric hollow-bead delivery system or methacrylated polymerizable Irgasan (Antibacterial B), while one specimen served as an unmodified control (ST). A delivery system based on Poly-Pore® was loaded with one of the active agents: Tego® Protect 5000 (Antiadhesive A), Dimethicone (Antiadhesive B), or Irgasan (Antibacterial A). All study subjects refrained from toothbrushing during the study period. Specimens were detached from the splints after 8 h and given a live/dead staining before fluorescence microscopy. A Friedman test and a post hoc Nemenyi test were applied with a significance level at p < 0.05. In summary, all materials but Antibacterial B showed a significant antibacterial effect compared to ST. The results suggested the role of the materials\' chemistry in the dominance of cell adhesion. In conclusion, dental resin composites with Poly-Pore-loaded active agents showed antibacterial effectiveness in situ.
摘要：
研究的目的是研究实验改性牙科树脂复合材料表面初始生物膜的细菌活力。本研究包括25名口腔卫生良好的健康个体。在裂口设计中，他们收到了带有五个实验性复合树脂标本的丙烯酸夹板。其中四个用新型聚合物空心微珠递送系统或甲基丙烯酸酯化可聚合Irgasan（抗菌B）进行了修饰，而一个样本用作未修饰的对照（ST）。基于Poly-Pore®的递送系统装载有活性剂之一:Tego®Protect5000(抗粘连剂A),聚二甲基硅氧烷(防粘剂B),或Irgasan（抗菌A）。所有研究对象在研究期间避免刷牙。8小时后将样品从夹板上分离,并在荧光显微镜检查前给予活/死染色。应用Friedman检验和事后Nemenyi检验,显著性水平为p<0.05。总之,与ST相比，除抗菌B外的所有材料均显示出显着的抗菌作用。结果表明材料化学在细胞粘附的优势中的作用。总之,含有聚孔活性剂的牙科树脂复合材料显示出原位抗菌效果。
