PDF(Pubmed)
Abstract：
Multiple papulonodular skin lesions at birth can indicate the presence of various benign and malignant disorders. Although the lesions\' clinical aspect (color and consistency, in particular) may steer the clinician towards one disorder or another (infantile myofibromatosis, xanthogranuloma, or metastatic neuroblastoma), the diagnosis can only be confirmed by the histopathologic assessment of a biopsy. In neonates, a rapid but accurate diagnosis is critical because skin lesions may be the first manifestation of a malignant disorder like leukemia cutis or metastatic neuroblastoma. Here, we review the various disorders that may manifest themselves as multiple skin lesions at birth.
摘要：
出生时多发丘疹结节状皮肤病变可能表明存在各种良性和恶性疾病。虽然病变的临床方面(颜色和一致性，特别是）可能会引导临床医生转向一种或另一种疾病（婴儿肌纤维瘤病，黄色肉芽肿,或转移性神经母细胞瘤)，只有通过活检的组织病理学评估才能确认诊断.在新生儿中，快速而准确的诊断至关重要,因为皮肤病变可能是皮肤白血病或转移性神经母细胞瘤等恶性疾病的首发表现.这里,我们回顾了出生时可能表现为多发性皮肤病变的各种疾病。
