关键词: RAS-GEF SOS anthraquinones cancer inhibitors
Mesh : Animals Anthraquinones / pharmacology Antineoplastic Agents / pharmacology Cardiotoxicity / prevention & control Cell Line, Transformed Cell Line, Tumor Doxorubicin / pharmacology Epithelial Cells / drug effects metabolism pathology Fibroblasts / cytology drug effects metabolism GTP Phosphohydrolases / antagonists & inhibitors genetics metabolism Humans Idarubicin / pharmacology Membrane Proteins / antagonists & inhibitors genetics metabolism Mice Mice, Knockout Proto-Oncogene Proteins p21(ras) / antagonists & inhibitors genetics metabolism SOS1 Protein / genetics metabolism Small Molecule Libraries / pharmacology Son of Sevenless Proteins / deficiency genetics
来 源:
DOI:10.3390/biom11081128
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