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Abstract：
The neural crest (NC) is a multipotent and temporarily migratory cell population stemming from the dorsal neural tube during vertebrate embryogenesis. Cardiac neural crest cells (NCCs), a specified subpopulation of the NC, are vital for normal cardiovascular development, as they significantly contribute to the pharyngeal arch arteries, the developing cardiac outflow tract (OFT), cardiac valves, and interventricular septum. Various signaling pathways are shown to orchestrate the proper migration, compaction, and differentiation of cardiac NCCs during cardiovascular development. Any loss or dysregulation of signaling pathways in cardiac NCCs can lead to abnormal cardiovascular development during embryogenesis, resulting in abnormalities categorized as congenital heart defects (CHDs). This review focuses on the contributions of cardiac NCCs to cardiovascular formation, discusses cardiac defects caused by a disruption of various regulatory factors, and summarizes the role of multiple signaling pathways during embryonic development. A better understanding of the cardiac NC and its vast regulatory network will provide a deeper insight into the mechanisms of the associated abnormalities, leading to potential therapeutic advancements.
摘要：
神经c（NC）是脊椎动物胚胎发生过程中源于背侧神经管的多能且暂时迁移的细胞群。心脏神经c细胞（NCC），NC的指定子群体，对正常的心血管发育至关重要，因为它们对咽弓动脉有很大的贡献，发育中的心脏流出道（OFT），心脏瓣膜,和室间隔.各种信号通路被证明可以协调适当的迁移，压实,和心脏NCCs在心血管发育过程中的分化。心脏NCCs信号通路的任何丢失或失调都可能导致胚胎发生过程中的异常心血管发育。导致异常分类为先天性心脏缺陷（CHD）。本文综述了心脏NCCs对心血管形成的贡献。讨论了由各种调节因素的破坏引起的心脏缺陷，并总结了多种信号通路在胚胎发育过程中的作用。对心脏NC及其庞大的调节网络的更好理解将提供对相关异常机制的更深入的了解。导致潜在的治疗进步。
