PDF(Pubmed)
Abstract：
(1) Background. Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe mucocutaneous reactions, characterized by extensive necrosis and detachment of the epidermis. (2) Case presentation. We present a case of a 46-year-old patient with late-stage high-grade serous ovarian cancer who was primarily treated with neoadjuvant chemotherapy and interval debulking, which was followed by adjuvant chemotherapy. At first recurrence, she was again treated with chemotherapy, and due to severe abdominal pain, an elastomeric pump containing analgesics, anti-inflammatories, and ondansetron was administered. In the same month, she was admitted to the hospital due to severe dysphagia, and in the following days she developed haemorrhagic vesiculobullous lesions on the facial skin and trunk. Stevens-Johnson syndrome was confirmed and ondansetron as a plausible leading cause was discontinued. Despite multimodal treatment, her condition deteriorated, and she died. (3) Discussion and conclusion. Although gynaecologists rarely encounter Stevens-Johnson syndrome, high mortality of the disease should ensure a low threshold for diagnosing and treating this disease.
摘要：
（1）背景。Stevens-Johnson综合征（SJS）和中毒性表皮坏死松解症（TEN）是严重的粘膜皮肤反应，以表皮广泛坏死和脱离为特征。（2）案例介绍。我们介绍了一例46岁的晚期高级别浆液性卵巢癌患者，主要接受新辅助化疗和间隔减积治疗，随后是辅助化疗。第一次复发时，她又接受了化疗,由于严重的腹痛,含有镇痛药的弹性泵，抗炎药,服用了昂丹司琼。同月,她因严重吞咽困难入院,在接下来的几天里，她在面部皮肤和躯干上出现了出血性泡状病变。史蒂文斯-约翰逊综合征被证实，昂丹司琼作为一个可能的主要原因被停用。尽管进行了多模式治疗,她的病情恶化了,她死了.（3）讨论与结论。尽管妇科医生很少遇到史蒂文斯-约翰逊综合征，该疾病的高死亡率应确保诊断和治疗该疾病的低门槛。
