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Abstract：
BACKGROUND: Inadequate meibomian glands (MGs) secretion can lead to dry eye signs and symptoms. Tear film lipid layer (TFLL) secreted by MGs protects and prevents rapid evaporation of tear film. The purpose was to assess TFLL alteration and function in patients with evaporative dry eye (EDE) using tear interferometry after optimal pulse light technology (OPT) intense pulsed light (IPL).
METHODS: This prospective randomized examiner-masked sham- controlled study included 86 participants (142 eyes) with DED. IPL or sham procedure was performed on day 0, 21, and 42. Ocular Surface Disease Index (OSDI), non-invasive breakup time (NITBUT), interferometric fringe pattern determined TFLL quality, fluorescein staining (FS), and meibum gland (MG) were assessed at day 0, 21, 42 and 3-month.
RESULTS: At 3-month, TFLL, NITBUT, MG drop-out, MG quality, MG expressibility, FS and OSDI improved significantly (P < 0.05) in the IPL group, while the sham group had no significant improvements. Except for Meibo-score and FS, all parameters significantly correlated with the improvement in TFLL following IPL treatment. Additionally, artificial tears usage was significantly less in the IPL group from D-42 onwards.
CONCLUSIONS: IPL treatment demonstrated the ability to improve TFLL quality and clinically reduced sign and symptoms of DED thereby reducing the frequency of artificial tears use.
METHODS: This prospective randomized examiner-masked sham- controlled study included 86 participants (142 eyes) with DED. IPL or sham procedure was performed on day 0, 21, and 42. Ocular Surface Disease Index (OSDI), non-invasive breakup time (NITBUT), interferometric fringe pattern determined TFLL quality, fluorescein staining (FS), and meibum gland (MG) were assessed at day 0, 21, 42 and 3-month.
RESULTS: At 3-month, TFLL, NITBUT, MG drop-out, MG quality, MG expressibility, FS and OSDI improved significantly (P < 0.05) in the IPL group, while the sham group had no significant improvements. Except for Meibo-score and FS, all parameters significantly correlated with the improvement in TFLL following IPL treatment. Additionally, artificial tears usage was significantly less in the IPL group from D-42 onwards.
CONCLUSIONS: IPL treatment demonstrated the ability to improve TFLL quality and clinically reduced sign and symptoms of DED thereby reducing the frequency of artificial tears use.
摘要：
背景：睑板腺（MGs）分泌不足可导致干眼症和症状。由MGs分泌的泪膜脂质层(TFLL)保护并防止泪膜的快速蒸发。目的是在最佳脉冲光技术（OPT）强脉冲光（IPL）后使用泪液干涉法评估蒸发性干眼（EDE）患者的TFLL改变和功能。
方法：这项前瞻性随机对照研究包括86名DED患者（142只眼）。在第0、21和42天进行IPL或假手术。眼表疾病指数（OSDI），非侵入性破裂时间（NITBUT），干涉条纹图案确定TFLL质量，荧光素染色（FS），在第0、21、42和3个月时评估和meiburm腺（MG）。
结果：在3个月时，TFLL,NITBUT,MG辍学,MG质量,MG表现力，IPL组FS和OSDI明显改善(P<0.05),而假手术组无显著改善。除了Meibo-score和FS,所有参数均与IPL治疗后TFLL的改善显着相关。此外,从D-42开始,IPL组的人工泪液使用量明显减少.
结论：IPL治疗显示出改善TFLL质量的能力，并在临床上减少了DED的体征和症状，从而减少了人工泪液的使用频率。
方法：这项前瞻性随机对照研究包括86名DED患者（142只眼）。在第0、21和42天进行IPL或假手术。眼表疾病指数（OSDI），非侵入性破裂时间（NITBUT），干涉条纹图案确定TFLL质量，荧光素染色（FS），在第0、21、42和3个月时评估和meiburm腺（MG）。
结果：在3个月时，TFLL,NITBUT,MG辍学,MG质量,MG表现力，IPL组FS和OSDI明显改善(P<0.05),而假手术组无显著改善。除了Meibo-score和FS,所有参数均与IPL治疗后TFLL的改善显着相关。此外,从D-42开始,IPL组的人工泪液使用量明显减少.
结论：IPL治疗显示出改善TFLL质量的能力，并在临床上减少了DED的体征和症状，从而减少了人工泪液的使用频率。
