METHODS: This prospective randomized examiner-masked sham- controlled study included 86 participants (142 eyes) with DED. IPL or sham procedure was performed on day 0, 21, and 42. Ocular Surface Disease Index (OSDI), non-invasive breakup time (NITBUT), interferometric fringe pattern determined TFLL quality, fluorescein staining (FS), and meibum gland (MG) were assessed at day 0, 21, 42 and 3-month.
RESULTS: At 3-month, TFLL, NITBUT, MG drop-out, MG quality, MG expressibility, FS and OSDI improved significantly (P < 0.05) in the IPL group, while the sham group had no significant improvements. Except for Meibo-score and FS, all parameters significantly correlated with the improvement in TFLL following IPL treatment. Additionally, artificial tears usage was significantly less in the IPL group from D-42 onwards.
CONCLUSIONS: IPL treatment demonstrated the ability to improve TFLL quality and clinically reduced sign and symptoms of DED thereby reducing the frequency of artificial tears use.
方法:这项前瞻性随机对照研究包括86名DED患者(142只眼)。在第0、21和42天进行IPL或假手术。眼表疾病指数(OSDI),非侵入性破裂时间(NITBUT),干涉条纹图案确定TFLL质量,荧光素染色(FS),在第0、21、42和3个月时评估和meiburm腺(MG)。
结果:在3个月时,TFLL,NITBUT,MG辍学,MG质量,MG表现力,IPL组FS和OSDI明显改善(P<0.05),而假手术组无显著改善。除了Meibo-score和FS,所有参数均与IPL治疗后TFLL的改善显着相关。此外,从D-42开始,IPL组的人工泪液使用量明显减少.
结论:IPL治疗显示出改善TFLL质量的能力,并在临床上减少了DED的体征和症状,从而减少了人工泪液的使用频率。