PDF(Pubmed)
Abstract：
Recent developments have given more credence into the brain-gut-microbiota axis and its role in the development of tumor genesis. The microbiota have multiple functions including maintenance of the epithelial barrier, immune response, digestion, cortisol regulation, and control of neurotransmitters and their metabolism [e.g., serotonin, dopamine, noradrenaline and gamma-Aminobutyric Acid (GABA)]. Changes in gut microbiota can interfere with homeostasis leading to dysbiosis microbiota, which is linked to colorectal cancer. Microbiota composition can cause pronounced effect on medical interventions including medications, chemotherapy, and radiation. Altered primary immune system is associated with microbiota disassociation and development of colorectal cancer. This article reviews the current research in brain-gut axis with focus on microbiota and its role in the development of gastrointestinal cancers. We conducted a literature review on PubMed, Cochrane, and Science direct using English language. We begin by reviewing the brain-gut axis and its function and then discuss its effect on the development of gastrointestinal cancers. We reviewed 70 manuscripts and found association between microbiota dysfunction and development of colorectal cancers predisposing to psychiatric manifestations. Lasting disturbances in the microbiota can lead to systemic inflammation with implications on disease development or treatment modifications. These disruptions of the intestinal flora can play an important role in the pathogenesis of cancers. Most psychological reactions to cancer are similar across cancer types but each cancer when examined individually has its own unique features associated with it. Correlation between fear of recurrence and the level of pathological distress is viewed as an indicator of overall adjustment to cancer survival.
摘要：
最近的发展使脑-肠-微生物群轴及其在肿瘤发生发展中的作用得到了更多的信任。微生物群具有多种功能，包括维持上皮屏障，免疫反应，消化，皮质醇调节,和控制神经递质及其代谢[例如，血清素,多巴胺,去甲肾上腺素和γ-氨基丁酸（GABA）]。肠道微生物群的变化可以干扰稳态，导致菌群失调，这与结直肠癌有关。微生物组成可以对包括药物在内的医疗干预措施产生显著影响，化疗,和辐射。原发性免疫系统的改变与大肠癌的微生物群解体和发展有关。本文综述了目前关于脑-肠轴的研究，重点是微生物群及其在胃肠道肿瘤发生发展中的作用。我们对PubMed进行了文献综述，科克伦,和科学直接使用英语。我们首先回顾了脑-肠轴及其功能，然后讨论了其对胃肠道癌症发展的影响。我们回顾了70篇手稿，发现微生物群功能障碍与结直肠癌易诱发精神病表现之间存在关联。微生物群的持久紊乱可导致全身性炎症，对疾病发展或治疗改变有影响。这些肠道菌群的破坏可以在癌症的发病机理中起重要作用。对癌症的大多数心理反应在癌症类型之间是相似的，但是每种癌症在单独检查时都有其独特的特征。对复发的恐惧与病理困扰水平之间的相关性被视为对癌症生存率的总体调整的指标。
