PDF(Pubmed)
Abstract：
BACKGROUND: Transurethral resection of the prostate (TURP) is the gold standard for benign prostatic enlargement; however, hemorrhage still remains one of the major complications.
OBJECTIVE: The primary aim of this study was to evaluate the effect of tranexamic acid (TXA) in reducing intraoperative blood loss and need for blood transfusion. Secondary parameters compared were operating time, volume of irrigation fluid used, and reduction in hemoglobin concentration.
METHODS: A total of 70 eligible patients undergoing TURP were randomized based on computer generated table into two groups. The study group (1) received IV TXA 500 mg after induction of anesthesia and 500 mg in each irrigation fluid bottle (dual mode) and the control group (2) received none.
RESULTS: The mean age (68.20 vs. 66.5 years), prostate size (57 vs. 51 g), and preoperative hemoglobin (13.3 vs. 13.5 g/dl) were similar between the groups. Intraoperative blood loss in the TXA group was found to be significantly reduced (174.60 ± 125.38 ml vs. 232.47 ± 116.8; P = 0.04). Blood transfusion was required in 2.8% of cases as compared to 14.2% in controls. Operating time, volume of irrigation fluid, and postoperative reduction of hemoglobin were not significant between the groups. No complications were observed in both groups.
CONCLUSIONS: In this study, we observed that TXA, when used as a combination of Intravenous and topical route, effectively reduced intra-operative blood loss and the need for transfusion.
OBJECTIVE: The primary aim of this study was to evaluate the effect of tranexamic acid (TXA) in reducing intraoperative blood loss and need for blood transfusion. Secondary parameters compared were operating time, volume of irrigation fluid used, and reduction in hemoglobin concentration.
METHODS: A total of 70 eligible patients undergoing TURP were randomized based on computer generated table into two groups. The study group (1) received IV TXA 500 mg after induction of anesthesia and 500 mg in each irrigation fluid bottle (dual mode) and the control group (2) received none.
RESULTS: The mean age (68.20 vs. 66.5 years), prostate size (57 vs. 51 g), and preoperative hemoglobin (13.3 vs. 13.5 g/dl) were similar between the groups. Intraoperative blood loss in the TXA group was found to be significantly reduced (174.60 ± 125.38 ml vs. 232.47 ± 116.8; P = 0.04). Blood transfusion was required in 2.8% of cases as compared to 14.2% in controls. Operating time, volume of irrigation fluid, and postoperative reduction of hemoglobin were not significant between the groups. No complications were observed in both groups.
CONCLUSIONS: In this study, we observed that TXA, when used as a combination of Intravenous and topical route, effectively reduced intra-operative blood loss and the need for transfusion.
摘要：
背景：经尿道前列腺切除术（TURP）是良性前列腺肿大的金标准；然而，出血仍然是主要并发症之一。
目的：本研究的主要目的是评估氨甲环酸（TXA）在减少术中失血和输血需求方面的作用。比较的次要参数是运行时间，使用的冲洗液的体积，以及血红蛋白浓度的降低.
方法：根据计算机生成的表格，将70例符合条件的TURP患者随机分为两组。研究组（1）在麻醉诱导后接受静脉TXA500mg，在每个冲洗液瓶中接受500mg（双模式），对照组（2）没有接受。
结果：平均年龄（68.20vs.66.5年），前列腺大小（57vs.51g)，和术前血红蛋白（13.3vs.13.5g/dl）组间相似。TXA组术中出血量明显减少（174.60±125.38mlvs.232.47±116.8；P=0.04）。2.8%的病例需要输血，而对照组为14.2%。运行时间,冲洗液的体积，术后血红蛋白的减少在两组之间并不显著。两组均无并发症发生。
结论：在这项研究中，我们观察到TXA,当作为静脉和局部途径的组合使用时，有效减少术中失血和输血的需要。
目的：本研究的主要目的是评估氨甲环酸（TXA）在减少术中失血和输血需求方面的作用。比较的次要参数是运行时间，使用的冲洗液的体积，以及血红蛋白浓度的降低.
方法：根据计算机生成的表格，将70例符合条件的TURP患者随机分为两组。研究组（1）在麻醉诱导后接受静脉TXA500mg，在每个冲洗液瓶中接受500mg（双模式），对照组（2）没有接受。
结果：平均年龄（68.20vs.66.5年），前列腺大小（57vs.51g)，和术前血红蛋白（13.3vs.13.5g/dl）组间相似。TXA组术中出血量明显减少（174.60±125.38mlvs.232.47±116.8；P=0.04）。2.8%的病例需要输血，而对照组为14.2%。运行时间,冲洗液的体积，术后血红蛋白的减少在两组之间并不显著。两组均无并发症发生。
结论：在这项研究中，我们观察到TXA,当作为静脉和局部途径的组合使用时，有效减少术中失血和输血的需要。
