UNASSIGNED: We performed a case-control study, involving 22 cases and 19 controls. The cases were patients at the early stage of SVCI, which was defined as subcortical ischemic vascular disease with normal global cognitive measures (pre-SVCI). The controls were healthy people matched by age, sex, and education years. We assessed the differences in a battery of neuropsychological tests between the two groups, investigated the diffusion changes in 40 WM tracts among the participants via an atlas-based segmentation strategy, and compared the differences between the cases and controls by multiple linear regression analysis. We then evaluated the relationships between diffusion indices and cognitive assessment scores by Pearson\'s correlation.
UNASSIGNED: The pre-SVCI group exhibited significant differences in the Montreal cognitive assessment (MoCA), Rey-Osterrieth Complex Figure (R-O)-copy, and Trail Making Test (TMT)-B test compared with the controls. Compared with the controls, some long associative and projective bundles, such as the right anterior corona radiata (ACR), the right inferior fronto-occipital fasciculus (IFOF), and the left external capsule (EC), were extensively damaged in cases after Bonferroni correction (p < 0.05/40). Damages to specific fibers, such as the right ACR, IFOF, and posterior thalamic radiation (PTR), exhibited significant correlations with declines in MoCA, R-O delay, and the Mini-Mental State Examination (MMSE), respectively, after Bonferroni correction (p < 0.05/14).
UNASSIGNED: Long WM tracts, especially those in the right hemisphere, were extensively damaged in the pre-SVCI patients and correlated with declines in executive functions and spatial processing. Patients of pre-SVCI are likely at an ultra-early stage of SVCI, and there is a very high risk of this condition becoming SVCI.
■我们进行了病例对照研究,涉及22例病例和19例对照。这些病例是SVCI早期的患者,SVCI被定义为皮质下缺血性血管疾病,总体认知测量正常(前SVCI)。对照组是按年龄匹配的健康人,性别,教育年。我们评估了两组之间一系列神经心理学测试的差异,通过基于图集的分割策略,调查了40个WM束在参与者中的扩散变化,并通过多元线性回归分析比较病例与对照之间的差异。然后,我们通过Pearson相关性评估了扩散指数与认知评估得分之间的关系。
■前SVCI组在蒙特利尔认知评估(MoCA)中表现出显着差异,Rey-Osterrieth复杂图(R-O)-副本,以及与对照组比较的跟踪测试(TMT)-B测试。与对照组相比,一些长的联想和投影束,例如右前电晕辐射(ACR),右额枕骨下束(IFOF),和左外囊(EC),在Bonferroni矫正后的病例中被广泛损害(p<0.05/40)。对特定纤维的损害,比如正确的ACR,IFOF,和后丘脑辐射(PTR),与MoCA的下降表现出显著的相关性,R-O延迟,和迷你精神状态检查(MMSE),分别,Bonferroni校正后(p<0.05/14)。
■长WM段,尤其是那些在右半球,在前SVCI患者中广泛受损,并与执行功能和空间处理的下降相关。前SVCI患者可能处于SVCI的超早期阶段,并且这种疾病成为SVCI的风险非常高。