METHODS: We undertook a systematic review and meta-analysis, using PubMed, EMBASE, Scopus and the Cochran Library and hand-searching published papers. The random-effects model meta-analysis was used to calculate pooled estimated odd ratios with the corresponding 95% confidence interval.
RESULTS: All studies in the systematic review (n = 25) and the meta-analysis (n = 12) were hospital-based. Seven only included children. Relatively few studies have been published in the last decade, the majority of which are from high-income temperate settings. Staphylococcus aureus was the main organism isolated. Males under the age of 20 predominated, and mortality of up to 20% was reported. Factors associated with pyomyositis were HIV infection (OR = 4.82; 95% CI: 1.67-13.92) and fulfilling an AIDS surveillance definition (OR = 6.08; 95% CI: 2.79-13.23).
CONCLUSIONS: Our meta-analysis indicated significant associations between pyomyositis infection and HIV/AIDS. Major gaps in our understanding of the epidemiology, pathogenesis, clinical presentation, and outcome remain, highlighting the need for further research and more systematic studies. Pyomyositis merits consideration as a neglected tropical disease.
方法:我们进行了系统综述和荟萃分析,使用PubMed,EMBASE,Scopus和Cochran图书馆和手工搜索发表的论文。随机效应模型荟萃分析用于计算合并估计的奇数比率以及相应的95%置信区间。
结果:系统评价(n=25)和荟萃分析(n=12)中的所有研究均以医院为基础。七个只包括孩子。在过去的十年中,发表的研究相对较少,其中大部分来自高收入温带环境。金黄色葡萄球菌是分离的主要细菌。20岁以下的男性占主导地位,据报道死亡率高达20%。与化脓性肌炎相关的因素是HIV感染(OR=4.82;95%CI:1.67-13.92)和符合AIDS监测定义(OR=6.08;95%CI:2.79-13.23)。
结论:我们的荟萃分析表明化脓性肌炎感染与HIV/AIDS之间存在显著关联。我们对流行病学的理解存在重大差距,发病机制,临床表现,结果仍然存在,强调需要进一步研究和更系统的研究。化脓性肌炎作为一种被忽视的热带病值得考虑。