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Abstract：
The aim of this study was to evaluate blood perfusion of the renal cortex during ischemia-reperfusion (I/R) injury using quantitative contrast-enhanced ultrasound (CEUS) parameters. In this experiment, 24 rabbits were randomly divided into four groups (N = 6): sham-operated group, 24-h post-operation for I/R injury group (24-h I/R), 3-d post-operation for I/R injury group (3-d I/R) and 5 d post-operation for I/R injury group (5 d I/R). All quantitative CEUS parameters were monitored and included the gradient from the start frame to the peak frame (Grad), area under the curve (Area), time-to-peak (TTP), difference between B(intercept intensity at t=0) and A(the intensity attenuation t= 0) and arrival time (AT). Subsequently, we analyzed the changes in these parameters, as well as the correlation between changes in CEUS parameters and pathological parameters. AT and TTP values peaked 3 d after I/R surgery, which correlated with the most significant pathological changes at the same time point. These parameters (such as AT, TTP and Grad) may be useful in dynamically monitoring the severity of tissue damage at the early stage of I/R injury.
摘要：
这项研究的目的是使用定量对比增强超声（CEUS）参数评估缺血再灌注（I/R）损伤期间肾皮质的血液灌注。在这个实验中,24只家兔随机分为4组(N=6):假手术组,I/R损伤组术后24小时（24小时I/R），I/R损伤组术后3d（3dI/R），I/R损伤组术后5d（5dI/R）。监测所有定量CEUS参数,包括从起始帧到峰值帧的梯度(Grad),曲线下的面积（面积），峰值时间（TTP），B（t=0时的截距强度）和A（强度衰减t=0）与到达时间（AT）之间的差。随后，我们分析了这些参数的变化，以及CEUS参数变化与病理参数之间的相关性。AT和TTP值在I/R手术后3d达到峰值，与同一时间点最显著的病理变化相关。这些参数(如AT、TTP和Grad）可用于在I/R损伤的早期动态监测组织损伤的严重程度。
