Abstract：
OBJECTIVE: Negative pressure wound therapy on closed incisions (iNPWT) is a wound dressing system developed to promote wound healing and avoid complications after surgical procedures. The effect of iNPWT is well established in various surgical fields, however, the effect on postoperative wound complications after ventral hernia repair remains unknown. The aim of this systematic review and meta-analysis was to investigate the effect of iNPWT on patients undergoing open ventral hernia repair (VHR) compared with conventional wound dressing.
METHODS: This systematic review and meta-analysis followed the PRISMA guidelines. The databases PubMed, Embase, Cochrane Library, Web of science and Cinahl were searched for original studies comparing iNPWT to conventional wound dressing in patients undergoing VHR. The primary outcome was surgical site occurrence (SSO), secondary outcomes included surgical site infection (SSI) and hernia recurrence.
RESULTS: The literature search identified 373 studies of which 10 were included in the meta-analysis including a total of 1087 patients. Eight studies were retrospective cohort studies, one was a cross-sectional pilot study, and one was a randomized controlled trial. The meta-analysis demonstrated that iNPWT was associated with a decreased risk of SSO (OR 0.27 [0.19, 0.38]; P < 0.001) and SSI (OR 0.32 [0.17, 0.55]; P < 0.001). There was no statistically significant association with the risk of hernia recurrence (OR 0.62 [0.27, 1.43]; P = 0.26).
CONCLUSIONS: Based on the findings of this systematic review and meta-analysis iNPWT following VHR was found to significantly reduce the incidence of SSO and SSI, compared with standard wound dressing. INPWT should be considered for patients undergoing VHR.
METHODS: This systematic review and meta-analysis followed the PRISMA guidelines. The databases PubMed, Embase, Cochrane Library, Web of science and Cinahl were searched for original studies comparing iNPWT to conventional wound dressing in patients undergoing VHR. The primary outcome was surgical site occurrence (SSO), secondary outcomes included surgical site infection (SSI) and hernia recurrence.
RESULTS: The literature search identified 373 studies of which 10 were included in the meta-analysis including a total of 1087 patients. Eight studies were retrospective cohort studies, one was a cross-sectional pilot study, and one was a randomized controlled trial. The meta-analysis demonstrated that iNPWT was associated with a decreased risk of SSO (OR 0.27 [0.19, 0.38]; P < 0.001) and SSI (OR 0.32 [0.17, 0.55]; P < 0.001). There was no statistically significant association with the risk of hernia recurrence (OR 0.62 [0.27, 1.43]; P = 0.26).
CONCLUSIONS: Based on the findings of this systematic review and meta-analysis iNPWT following VHR was found to significantly reduce the incidence of SSO and SSI, compared with standard wound dressing. INPWT should be considered for patients undergoing VHR.
摘要：
目的：闭合切口负压伤口治疗（iNPWT）是一种伤口敷料系统，旨在促进伤口愈合并避免外科手术后的并发症。iNPWT的效果在各种外科领域都得到了证实，然而,对腹侧疝修补术后伤口并发症的影响尚不清楚.这项系统评价和荟萃分析的目的是研究iNPWT与常规伤口敷料相比对开放式腹侧疝修补术（VHR）患者的影响。
方法：本系统综述和荟萃分析遵循PRISMA指南。数据库PubMed,Embase,科克伦图书馆,在Webofscience和Cinahl中搜索了将iNPWT与接受VHR的患者的常规伤口敷料进行比较的原始研究。主要结果是手术部位发生（SSO），次要结局包括手术部位感染(SSI)和疝复发.
结果：文献检索确定了373项研究，其中10项纳入荟萃分析，共包括1087名患者。8项研究为回顾性队列研究,一个是横断面试点研究，一项是随机对照试验.荟萃分析显示iNPWT与SSO(OR0.27[0.19,0.38];P<0.001)和SSI(OR0.32[0.17,0.55];P<0.001)风险降低相关。与疝气复发的风险无统计学意义（OR0.62[0.27,1.43]；P=0.26）。
结论：根据本系统综述和荟萃分析的结果，发现VHR后iNPWT显着降低SSO和SSI的发生率，与标准伤口敷料相比。对于接受VHR的患者应考虑INPWT。
方法：本系统综述和荟萃分析遵循PRISMA指南。数据库PubMed,Embase,科克伦图书馆,在Webofscience和Cinahl中搜索了将iNPWT与接受VHR的患者的常规伤口敷料进行比较的原始研究。主要结果是手术部位发生（SSO），次要结局包括手术部位感染(SSI)和疝复发.
结果：文献检索确定了373项研究，其中10项纳入荟萃分析，共包括1087名患者。8项研究为回顾性队列研究,一个是横断面试点研究，一项是随机对照试验.荟萃分析显示iNPWT与SSO(OR0.27[0.19,0.38];P<0.001)和SSI(OR0.32[0.17,0.55];P<0.001)风险降低相关。与疝气复发的风险无统计学意义（OR0.62[0.27,1.43]；P=0.26）。
结论：根据本系统综述和荟萃分析的结果，发现VHR后iNPWT显着降低SSO和SSI的发生率，与标准伤口敷料相比。对于接受VHR的患者应考虑INPWT。
