雷公藤甲素和 Ce6 与光活化脂质体的协同递送用于有效的肝细胞癌治疗。
关键词: ALT, liver-related alanine aminotransferase AST, aspartate aminotransferase BCA, bicinchoninic acid BUN, blood urea nitrogen CK, creatine kinase CK-MB, creatine kinase-MB CLSM, confocal laser scanning microscopy Ce6 Chol, cholesterol Cr, creatinine DEE, drug encapsulation efficiency DLC, drug loading content DLS, dynamic light scattering DSPG, distearoyl phosphatidylglycerole Dox, doxorubicin EPR, enhanced permeability and retention FBS, fetal bovine serum FCM, flow cytometry HCC, hepatocellular carcinoma Hepatocellular carcinoma LDH, lactate dehydrogenase LP, liposomes NIR, near-infrared PDT, photodynamic therapy PDX model PDX, patient-derived xenograft PDXHCC, patient derived tumor xenograft of HCC PI, propidium iodide Photo-activatable liposomes Photosensitizer Process of photodynamic therapy Pt, platinum ROS, reactive oxygen species So, sorafenib Synergetic delivery TEM, transmission electron microscope TP, triptolide TP/Ce6-LP, liposomes integrated with both photosensitizer Ce6 and chemotherapeutic drug TP TUNEL, dT-mediated dUTP Nick-End Labeling Triptolide
来 源:
DOI:10.1016/j.apsb.2021.02.001
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