NAD + 补充剂通过挽救肿瘤浸润 T 细胞中缺陷 TUB 介导的 NAMPT 转录来增强肿瘤杀伤功能。
关键词: CAR-T NAD(+) supplement NAMPT PD-1 T cell activation TUB cancer immunotherapy
Mesh : Adaptor Proteins, Signal Transducing / metabolism Adoptive Transfer Animals Cell Death / drug effects Cell Line, Tumor Energy Metabolism / drug effects Humans Lymphocyte Activation / drug effects Lymphocytes, Tumor-Infiltrating / drug effects immunology Mice, Inbred NOD NAD / pharmacology Neoplasms / genetics immunology pathology Nicotinamide Phosphoribosyltransferase / genetics metabolism T-Lymphocytes / drug effects immunology Transcription, Genetic / drug effects Mice
来 源:
DOI:10.1016/j.celrep.2021.109516
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