关键词: Cajal-Retzius cells Cat Early postnatal ontogenesis Heavy-chain neurofilaments Primary visual cortex SMI-32 antibody

来  源:   DOI:10.1016/j.neulet.2021.136165   PDF(Sci-hub)

Abstract:
Cajal-Retzius cells are one of the transient elements of the developing cerebral cortex. These cells express some characteristic molecules. One of them, heavy-chain neurofilaments, participating in the construction of the mature cerebral networks, are believed to be a specific feature of the human\'s Cajal-Retzius cells. Using histochemical stain for SMI-32 antibody to the non-phosphorylated heavy-chain neurofilaments, large neurons having horizontally oriented soma and bipolar processes were labeled in the molecular layer of the primary visual cortex of cats aged 0-2 postnatal days. Using DiI technique, similar neurons having a well-developed system of parallel vertical branches coming from the two horizontal processes were visualized in these areas. The location and general morphology of these neurons were similar to the Cajal-Retzius cells allowing to suppose for the carnivores to share similar with primates developmental mechanisms of the corticogenesis.
摘要:
Cajal-Retzius细胞是发育中的大脑皮层的瞬时元素之一。这些细胞表达一些特征性分子。其中一个,重链神经丝,参与成熟大脑网络的建设,被认为是人类Cajal-Retzius细胞的特定特征。使用SMI-32抗体对非磷酸化重链神经丝进行组织化学染色,在出生后0-2天的猫的初级视觉皮层的分子层中标记了具有水平定向的体细胞和双极过程的大神经元。使用DiI技术,在这些区域中,可以看到具有发达的来自两个水平过程的平行垂直分支系统的类似神经元。这些神经元的位置和一般形态与Cajal-Retzius细胞相似,从而可以假设食肉动物与灵长类动物的皮质发育机制相似。
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