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Abstract：
The purpose of this study is to investigate physicians\' knowledge, attitudes and practice of generic medicine substitutions in China. We conducted a cross-sectional online questionnaire survey on physicians from secondary or tertiary hospitals in China from 2020 December to 2021 April. Descriptive statistical and ordered logistic regression were used for analysis. A total of 1225 physicians were included in the final analysis, and only 330 (26.94%) of them scored 4 or above in the knowledge part, which means that the physicians have a good knowledge of generic substitutions. Of the total, 586 (47.83%) agreed or strongly agreed that generic drugs could be substituted for originator drugs and 585 (47.75%) always or often prescribed generic medicines. The percentage of physicians with a positive attitude toward or that practice prescribing generic medicine is below 50%, which needs to be improved in China. Physicians\' knowledge, their attitude toward generic substitution, if familiar with the policy of generic substitution, and incentives for prescribing generic medicines are influencing factors for the practice of generic substitution. Our studies show that the practice of generic substitution by physicians could be improved by several measures in China. We suggested that the physicians should be taught more about the bulk-buy policy and the generic-originator equivalence evaluation policy. Moreover, government incentives to promote generic substitution should be established. Our study also suggested that physicians with less working experience and female physicians should learn more about generic substitution.
摘要：
这项研究的目的是调查医生的知识，中国仿制药替代的态度和实践。我们于2020年12月至2021年4月对中国二级或三级医院的医师进行了横断面在线问卷调查。描述性统计和有序逻辑回归用于分析。共有1225名医生被纳入最终分析，只有330人(26.94%)在知识部分得分4分或以上，这意味着医生对通用替换有很好的了解。在总数中，586（47.83％）同意或强烈同意仿制药可以代替原始药物，585（47.75％）总是或经常开仿制药。对处方仿制药持积极态度的医生比例低于50%，这在中国需要改进。内科医生的知识，他们对通用替换的态度，如果熟悉通用替代的政策，和仿制药处方的激励因素是仿制药替代实践的影响因素。我们的研究表明，在中国，可以通过多种措施改善医师的通用替代做法。我们建议应向医生教授更多有关批量购买政策和仿制药等效性评估政策的知识。此外，应建立促进通用替代的政府激励措施。我们的研究还建议，工作经验较少的医生和女医生应该更多地了解通用替代。
