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Abstract：
Photoacoustic (PA) imaging is an emerging imaging modality that combines the advantages of optical imaging and ultrasound imaging. In particular, activatable PA probes, which visualize the presence or the activity of target molecules in terms of a change of the PA signal, are useful tools for functional imaging. In this chapter, we describe the development of small-molecule-based activatable PA probes, focusing on the design and synthesis of PA-MMSiNQ, our recently developed activatable PA probe for HOCl. We also describe the protocols used for evaluation of PA-MMSiNQ with a UV-vis spectrometer and a PA imaging microscope.
摘要：
光声（PA）成像是一种新兴的成像模式，它结合了光学成像和超声成像的优点。特别是,可激活PA探头,根据PA信号的变化可视化目标分子的存在或活性，是功能成像的有用工具。在这一章中,我们描述了基于小分子的可激活PA探针的发展，专注于PA-MMSiNQ的设计和合成，我们最近开发的用于HOCl的可激活PA探针。我们还描述了使用UV-vis光谱仪和PA成像显微镜评估PA-MMSiNQ的协议。
