PDF(Pubmed)
Abstract：
Autophagy is a cellular process that eliminates unnecessary cytoplasmic materials, such as long-age proteins, destroyed organelles, and foreign microorganisms. Macroautophagy (MaA), chaperone-mediated autophagy, and microautophagy are the three main types of autophagy. It is regulated by the integration of signaling from the AMPK and mTOR-ULK1 pathways. Autophagy plays a physiological role in health, and its dysregulation could be a pathophysiologic mechanism in different disease conditions. In the current study, we reviewed papers of Google Scholar database, PubMed, PubMed Central, Cochrane Database of Systematic Reviews, MEDLINE, and MedlinePlus with no time limitation and a recent World Health Organization report. In the current review, it could be concluded that autophagy plays many physiological functions, including immune system modulation, and regulates different cellular processes such as metabolism, protein synthesis, and cellular transportation. Dysregulation of autophagy is implicated in tumorigenesis, aging, age-related neurodegeneration, and endothelial dysfunctions. Autophagy dysregulation is also implicated in the newly discovered CoV-COVID-19 pathogenesis.
摘要：
自噬是消除不必要的细胞质物质的细胞过程，比如长期蛋白质，破坏了细胞器,和外来微生物。巨自噬(MaA),伴侣介导的自噬，和微自噬是自噬的三种主要类型。它受来自AMPK和mTOR-ULK1通路的信号整合的调节。自噬在健康中起着生理作用，其失调可能是不同疾病状态下的病理生理机制。在目前的研究中,我们查阅了谷歌学者数据库的论文，PubMed,PubMedCentral,Cochrane系统评价数据库，MEDLINE,和MedlinePlus没有时间限制和最近的世界卫生组织报告。在当前的审查中，可以得出结论，自噬发挥着许多生理功能，包括免疫系统的调节,并调节不同的细胞过程，如新陈代谢，蛋白质合成，和细胞运输。自噬的失调与肿瘤发生有关，老化，与年龄相关的神经变性，和内皮功能障碍。自噬失调也与新发现的CoV-COVID-19发病机制有关。
