PDF(Pubmed)
Abstract：
Cardiac allograft vasculopathy (CAV) is a pathologic immune-mediated remodelling of the vasculature in transplanted hearts and, by impairing perfusion, is the major cause of late graft loss. Although best understood following cardiac transplantation, similar forms of allograft vasculopathy occur in other vascularized organ grafts and some features of CAV may be shared with other immune-mediated vasculopathies. Here, we describe the incidence and diagnosis, the nature of the vascular remodelling, immune and non-immune contributions to pathogenesis, current therapies, and future areas of research in CAV.
摘要：
心脏同种异体移植血管病变（CAV）是一种病理性免疫介导的移植心脏血管重塑，通过损害灌注，是晚期移植物丢失的主要原因。虽然心脏移植后最容易理解，在其他血管化器官移植物中也有类似形式的同种异体血管病变,CAV的某些特征可能与其他免疫介导的血管病变相同.这里,我们描述了发病率和诊断，血管重塑的性质，免疫和非免疫对发病机理的贡献，目前的疗法，以及CAV未来的研究领域。
