Abstract:
Rodenticide or \'rat poison\' is easily available in a predominantly agrarian economy such as India. Metal phosphides or yellow phosphorous are two common rodenticides. Acute liver failure caused by accidental or suicidal poisoning with rodenticides has been infrequently reported in literature. Liver transplantation offers the best chances of survival in severe intoxication. However, the availability of liver transplantation in resource-limited settings presents a challenge. N-acetyl cysteine has been successfully used in paracetamol poisoning. Its use in rodenticide-induced acute liver failure is not so well known. We report three cases of rodenticide-related acute liver failure, one of them being a pregnant lady. All three patients were given N-acetyl cysteine and two patients improved. It is possible that the administration of N-acetyl cysteine contributed to the improvement in these two.
摘要:
杀鼠剂或“鼠药”在印度等以农业为主的经济体中很容易获得。金属磷化物或黄磷是两种常见的杀鼠剂。文献中很少报道由灭鼠剂的意外或自杀中毒引起的急性肝功能衰竭。肝移植提供了在严重中毒中生存的最佳机会。然而,在资源有限的环境中进行肝移植是一项挑战.N-乙酰半胱氨酸已成功用于扑热息痛中毒。其在杀鼠剂诱导的急性肝衰竭中的用途并不那么为人所知。我们报告了三例与杀鼠剂相关的急性肝衰竭,其中一个是孕妇.所有3例患者均给予N-乙酰半胱氨酸,2例患者改善。N-乙酰半胱氨酸的施用可能有助于这两者的改善。