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Abstract：
The objective of this meta-analysis was to evaluate the evidence on the effectiveness of glycerin trinitrate (NTG) measured by pain severity.
CENTRAL, MEDLINE, EMBASE, SCOPUS, and WEB of SCIENCE databases were searched in November 2020. The study selection was performed by two independent reviewers. The risk of systematic bias was assessed according to the Cochrane Collaboration\'s domain-based evaluation framework.
Of 87 identified records, the meta-analysis was conducted on eight RCTs. When grouping by the type of tendinopathy and combining the estimates obtained from all available time points, the pooled standardized difference in means (SMD) was -0.80 (95% CI -1.34 to -0.26), and the number needed to treat 3.53 (95% upper confidence limit 12.4). When combining all the available data (all types of tendinopathy and all time points), the pooled SMD was -1.57 (95% CI -2.47 to -0.67). Overall heterogeneity was high. The risk of systematic bias was low in most of the selected studies.
There is no evidence that NTG is more effective to reduce pain in tendinopathy than placebo. The effects of NTG were insignificant or borderline significant (probably insignificant clinically) concerning rotator cuff tendinopathy, Achilles tendinopathy, patellar tendinopathy, and lateral epicondylitis.IMPLICATIONS FOR REHABILITATIONA meta-analysis conducted on eight RCTs found no evidence that topical glycerin trinitrate is more effective to reduce pain in tendinitis than placebo.The effects were insignificant or borderline significant concerning rotator cuff tendinitis, Achilles tendinitis, patellar tendinitis, and lateral epicondylitis.The effects were independent of the dosage used.
CENTRAL, MEDLINE, EMBASE, SCOPUS, and WEB of SCIENCE databases were searched in November 2020. The study selection was performed by two independent reviewers. The risk of systematic bias was assessed according to the Cochrane Collaboration\'s domain-based evaluation framework.
Of 87 identified records, the meta-analysis was conducted on eight RCTs. When grouping by the type of tendinopathy and combining the estimates obtained from all available time points, the pooled standardized difference in means (SMD) was -0.80 (95% CI -1.34 to -0.26), and the number needed to treat 3.53 (95% upper confidence limit 12.4). When combining all the available data (all types of tendinopathy and all time points), the pooled SMD was -1.57 (95% CI -2.47 to -0.67). Overall heterogeneity was high. The risk of systematic bias was low in most of the selected studies.
There is no evidence that NTG is more effective to reduce pain in tendinopathy than placebo. The effects of NTG were insignificant or borderline significant (probably insignificant clinically) concerning rotator cuff tendinopathy, Achilles tendinopathy, patellar tendinopathy, and lateral epicondylitis.IMPLICATIONS FOR REHABILITATIONA meta-analysis conducted on eight RCTs found no evidence that topical glycerin trinitrate is more effective to reduce pain in tendinitis than placebo.The effects were insignificant or borderline significant concerning rotator cuff tendinitis, Achilles tendinitis, patellar tendinitis, and lateral epicondylitis.The effects were independent of the dosage used.
摘要：
这项荟萃分析的目的是评估通过疼痛严重程度衡量的甘油三硝酸酯（NTG）有效性的证据。
中央，MEDLINE,EMBASE,Scopus,和WEB的科学数据库在2020年11月进行了搜索。研究选择由两名独立的审阅者进行。根据CochraneCollaboration基于领域的评估框架评估系统偏差的风险。
在已确认的87条记录中,对8个RCTs进行了荟萃分析.当按肌腱病的类型进行分组并结合从所有可用时间点获得的估计值时，合并的标准化均值差异（SMD）为-0.80（95%CI-1.34至-0.26），和治疗所需的数量3.53（95％置信上限12.4）。当合并所有可用数据（所有类型的肌腱病和所有时间点）时，合并的SMD为-1.57（95%CI-2.47至-0.67）。总体异质性较高。在大多数选定的研究中，系统偏差的风险很低。
没有证据表明NTG比安慰剂更有效地减轻肌腱病的疼痛。关于肩袖肌腱病，NTG的影响不明显或边缘显着（可能在临床上不明显），跟腱病,髌骨肌腱病,外上髁炎.对8个RCT进行的康复的意义荟萃分析发现，没有证据表明局部甘油三硝酸酯比安慰剂更有效地减轻肌腱炎的疼痛。关于肩袖肌腱炎的影响不明显或临界显著，跟腱炎,髌骨肌腱炎,外上髁炎.效果与使用的剂量无关。
中央，MEDLINE,EMBASE,Scopus,和WEB的科学数据库在2020年11月进行了搜索。研究选择由两名独立的审阅者进行。根据CochraneCollaboration基于领域的评估框架评估系统偏差的风险。
在已确认的87条记录中,对8个RCTs进行了荟萃分析.当按肌腱病的类型进行分组并结合从所有可用时间点获得的估计值时，合并的标准化均值差异（SMD）为-0.80（95%CI-1.34至-0.26），和治疗所需的数量3.53（95％置信上限12.4）。当合并所有可用数据（所有类型的肌腱病和所有时间点）时，合并的SMD为-1.57（95%CI-2.47至-0.67）。总体异质性较高。在大多数选定的研究中，系统偏差的风险很低。
没有证据表明NTG比安慰剂更有效地减轻肌腱病的疼痛。关于肩袖肌腱病，NTG的影响不明显或边缘显着（可能在临床上不明显），跟腱病,髌骨肌腱病,外上髁炎.对8个RCT进行的康复的意义荟萃分析发现，没有证据表明局部甘油三硝酸酯比安慰剂更有效地减轻肌腱炎的疼痛。关于肩袖肌腱炎的影响不明显或临界显著，跟腱炎,髌骨肌腱炎,外上髁炎.效果与使用的剂量无关。
