Abstract：
Nuclear bodies are membrane-free nuclear substructures that are localized in the mammalian nuclear matrix region. They are multiprotein complexes that recruit other proteins to participate in various cellular activities, such as transcription, RNA splicing, epigenetic regulation, tumorigenesis and antiviral defense. It is of great significance to clarify the functions and regulatory mechanisms of nuclear bodies to probe related diseases and virus-host interactions. This review takes several nuclear bodies associated proteins as examples, summarizes the formation process, structure and functions of nuclear bodies, and focuses on their important roles in antiviral infection. It is expected to provide new insight into host antiviral mechanisms.
摘要：
核体是位于哺乳动物核基质区域的无膜核亚结构。它们是多蛋白复合物，招募其他蛋白质参与各种细胞活动，比如转录，RNA剪接,表观遗传调控，肿瘤发生和抗病毒防御。阐明核体的功能和调控机制对探索相关疾病和病毒-宿主相互作用具有重要意义。本文以几种核体相关蛋白为例,总结了形成过程，核体的结构和功能，并专注于它们在抗病毒感染中的重要作用。有望为宿主抗病毒机制提供新的见解。
