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Abstract：
Human parainfluenza virus type 3 (HPIV-3) may cause lower respiratory tract infection disease (LRTI-D) after hematopoietic stem cell transplantation (HSCT). Most previous have studies focused on recipients of HSCT whereas data on characteristics and outcomes in patients with hematological malignancies (HMs) compared to non-hematological patients are limited. The prognostic value of viral load in respiratory specimens remains elusive. In a 2-year retrospective study, we determined the frequencies of LRTI-D in HM, HSCT, and in non-hematological patients, and HPIV-3 levels in respiratory tract secretions. Among 98 patients with HPIV-3 infection, including 31 HSCT and 40 HM, 36 had a diagnosis of LRTI-D. LRTI-D was significantly more frequent in patients with HM or HSCT (n = 32, 45.1%) than in non-hematological patients (n = 4, 14.8%) (p = 0.006). The median HPIV-3 loads were high in upper respiratory tract secretions regardless of the presence or absence of LRTI-D (8.3 log10 vs. 7.6 log10 TCID50 /106 cells). HPIV-3 loads in respiratory tract samples in HM were not significantly higher than those found in HSCT but significantly higher than in non-hematological patients (p = 0.007). In conclusion, LRTI-D was frequent in HM patients who were diagnosed with HPIV-3 infection.
摘要：
人副流感病毒3型(HPIV-3)在造血干细胞移植(HSCT)后可引起下呼吸道感染疾病(LRTI-D)。大多数先前的研究都集中在HSCT的接受者上，而与非血液学患者相比，血液恶性肿瘤（HM）患者的特征和结局的数据有限。呼吸道标本中病毒载量的预后价值仍然难以捉摸。在一项为期2年的回顾性研究中，我们确定了LRTI-D在HM中的频率，HSCT,在非血液病患者中，和呼吸道分泌物中的HPIV-3水平。在98例HPIV-3感染患者中，包括31HSCT和40HM，36诊断为LRTI-D。患有HM或HSCT的患者（n=32，45.1％）的LRTI-D明显高于非血液学患者（n=4，14.8％）（p=0.006）。无论是否存在LRTI-D，上呼吸道分泌物中的HPIV-3负荷中位数都很高（8.3log10vs.7.6log10TCID50/106单元)。HM中呼吸道样本中的HPIV-3负荷并未显着高于HSCT中的负荷，但显着高于非血液学患者（p=0.007）。总之,LRTI-D在诊断为HPIV-3感染的HM患者中常见。
