PDF(Pubmed)
Abstract：
Diabetes mellitus is one of the foremost diseases in the modern era and diabetic nephropathy contributes to a major percentage of end-stage kidney disease. Although diabetic nephropathy is difficult to revert back, detection of nondiabetic renal disease (NDRD) is important to detect as most of them are treatable. We describe a case of a 62-year-old female with long-standing diabetes mellitus presenting with massive proteinuria and clinical features of nephrotic syndrome. The kidney biopsy showed class III diabetic nephropathy along with focal proliferative glomerulonephritis with crescent formations. The immunofluorescence study showed strong mesangial IgA deposition with the predominance of lambda stain. This confirmed the diagnosis of diabetic nephropathy with superimposed IgA nephropathy. We reviewed eight Indian studies herewith to demonstrate NDRD spectrum in the Indian diabetic scenario.
摘要：
糖尿病是现代最重要的疾病之一，糖尿病肾病是终末期肾病的主要原因。虽然糖尿病肾病很难恢复，非糖尿病肾病(NDRD)的检测非常重要,因为它们中的大多数是可治疗的.我们描述了一例62岁的女性，患有长期糖尿病，表现为大量蛋白尿和肾病综合征的临床特征。肾活检显示III类糖尿病肾病以及伴有新月形形成的局灶性增生性肾小球肾炎。免疫荧光研究显示，肾小球系膜IgA沉积强烈，以λ染色为主。这证实了糖尿病肾病合并IgA肾病的诊断。我们在此回顾了八项印度研究，以证明印度糖尿病患者的NDRD谱。
