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Abstract：
PH domain leucine-rich repeat protein phosphatase (PHLPP) is a family of enzymes made up of two isoforms (PHLPP1 and PHLPP2), whose actions modulate intracellular activity via the dephosphorylation of specific serine/threonine (Ser/Thr) residues on proteins such as Akt. Recent data generated in our lab, supported by findings from others, implicates the divergent roles of PHLPP1 and PHLPP2 in maintaining cellular homeostasis since dysregulation of these enzymes has been linked to various pathological states including cardiovascular disease, diabetes, ischemia/reperfusion injury, musculoskeletal disease, and cancer. Therefore, development of therapies to modulate specific isoforms of PHLPP could prove to be therapeutically beneficial in several diseases especially those targeting the cardiovascular system. This review is intended to provide a comprehensive summary of current literature detailing the role of the PHLPP isoforms in the development and progression of heart disease.
摘要：
PH域富含亮氨酸的重复蛋白磷酸酶（PHLPP）是由两种同工型（PHLPP1和PHLPP2）组成的酶家族，其作用通过蛋白质如Akt上的特定丝氨酸/苏氨酸(Ser/Thr)残基的去磷酸化来调节细胞内活性。我们实验室产生的最新数据，在其他人的发现的支持下，提示PHLPP1和PHLPP2在维持细胞稳态中的不同作用，因为这些酶的失调与包括心血管疾病在内的各种病理状态有关。糖尿病,缺血/再灌注损伤,肌肉骨骼疾病，和癌症。因此,开发调节PHLPP特定同工型的疗法可以证明对几种疾病特别是针对心血管系统的疾病在治疗上是有益的。这篇综述旨在提供当前文献的全面总结，详细介绍PHLPP亚型在心脏病发展和进展中的作用。
