Lenalidomide-Induced Myocarditis, Rare But Possibly Fatal Toxicity of a Commonly Used Immunotherapy.

来那度胺诱导的心肌炎,罕见但可能致命的毒性常用的免疫疗法。

• 发表时间: Nov 2020
• 来源期刊: JACC Case Rep
• DOI: 10.1016/j.jaccas.2020.07.033
• PMID: 34317115
• 文章类型: Case Reports
• 作者列表: Jacob R,Strati P,Palaskas N,Lopez-Mattei JC,Marmagkiolis K,Buja LM,Deswal A,Iliescu C

关键词: cardio-oncology; cardiotoxicity; follicular lymphoma; hsTnT, high-sensitivity troponin T; lenalidomide; myocarditis

Abstract

A 66-year-old woman with follicular lymphoma on lenalidomide and rituximab presented with chest pain. High-sensitivity troponin T peaked at 7,566 ng/l. Cardiac biopsy revealed extensive inflammation consistent with medication-induced myocarditis. Lenalidomide was stopped with improvement in troponins and patient was initiated on high-dose corticosteroid therapy. (Level of Difficulty: Intermediate.).

摘要

一名66岁的妇女，患有来那度胺和利妥昔单抗的滤泡性淋巴瘤，出现胸痛。高灵敏度肌钙蛋白T的峰值为7,566ng/l。心脏活检显示广泛的炎症与药物诱发的心肌炎一致。停止来那度胺并改善肌钙蛋白，并开始接受大剂量皮质类固醇治疗。（难度等级：中级。).