UNASSIGNED: A total of eight PALF cases aged 9 months to 14 years, weighing 10-50 kg., who were admitted to PICU King Chulalongkorn Memorial Hospital, Thailand and treated with TPE + HV-CRRT from January 2016 to September 2019 were reviewed. Patient demographic data, indications, technical aspects, and clinical outcomes were recorded.
UNASSIGNED: All patients who underwent TPE + HV-CRRT showed clinical improvement regarding serum bilirubin levels and coagulation studies after the therapy. Complications from the therapy were hemodynamic instability, symptomatic fluid overload, and bleeding from catheter sites. Among these, 6 (75%) patients survived with 4 (50%) successful LTs and 2 (25%) spontaneous recovery. Two children (25%) died while on the transplantation list.
UNASSIGNED: TPE + HV-CRRT can be used safely as a bridging therapy in children with PALF. As opposed to the adult population, higher volume of TPE or higher blood flow rate in pediatric patients might associate with hemodynamic instability during the procedure.
UNASSIGNED: Trepatchayakorn S, Chaijitraruch N, Chongsrisawat V, Chanakul A, Kongkiattikul L, Samransamruajkit R. Therapeutic Plasma Exchange with Continuous Renal Replacement Therapy for Pediatric Acute Liver Failure: A Case Series from Thailand. Indian J Crit Care Med 2021;25(7):812-816.
■共有8例9个月至14岁的PALF病例,重10-50公斤。,他们被送进了PICU朱拉隆功国王纪念医院,对2016年1月至2019年9月接受TPE+HV-CRRT治疗的泰国进行了回顾。患者人口统计数据,适应症,技术方面,并记录临床结局.
■所有接受TPE+HV-CRRT治疗的患者在治疗后血清胆红素水平和凝血研究方面均表现出临床改善。治疗的并发症是血流动力学不稳定,有症状的液体超负荷,还有导管部位的出血.其中,6例(75%)患者存活,4例(50%)成功的LTs和2例(25%)自发恢复。两名儿童(25%)在移植名单上死亡。
■TPE+HV-CRRT可安全用作PALF患儿的桥接治疗。与成年人相反,在儿科患者中,较高的TPE量或较高的血流速度可能与手术过程中的血流动力学不稳定有关.
■TrepatchayakornS,ChaijitraruchN,ChongsrisawatV,ChanakulA,KongkiattikulL,SamransamruajkitR.连续性肾脏替代治疗小儿急性肝衰竭的治疗性血浆置换:来自泰国的病例系列。印度JCritCareMed2021;25(7):812-816。