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Abstract：
Coronavirus disease (COVID-19) is a respiratory disease affecting many people and able to be transmitted through direct and perhaps indirect contact. Direct contact transmission, mediated by aerosols or droplets, is widely demonstrated, whereas indirect transmission is only supported by collateral evidence such as virus persistence on inanimate surfaces and data from other similar viruses. The present systematic review aims to estimate SARS-CoV-2 prevalence on inanimate surfaces, identifying risk levels according to surface characteristics. Data were obtained from studies in published papers collected from two databases (PubMed and Embase) with the last search on 1 September 2020. Included studies had to be papers in English, had to deal with coronavirus and had to consider inanimate surfaces in real settings. Studies were coded according to our assessment of the risk that the investigated surfaces could be contaminated by SARS-CoV-2. A meta-analysis and a metaregression were carried out to quantify virus RNA prevalence and to identify important factors driving differences among studies. Thirty-nine out of forty retrieved paper reported studies carried out in healthcare settings on the prevalence of virus RNA, five studies carry out also analyses through cell culture and six tested the viability of isolated viruses. Overall prevalences of SARS-CoV-2 RNA on high-, medium- and low-risk surfaces were 0.22 (CI95 [0.152-0.296]), 0.04 (CI95 [0.007-0.090]), and 0.00 (CI95 [0.00-0.019]), respectively. The duration surfaces were exposed to virus sources (patients) was the main factor explaining differences in prevalence.
摘要：
冠状病毒病(COVID-19)是一种影响许多人的呼吸道疾病，能够通过直接或间接接触传播。直接接触传输，由气溶胶或液滴介导，被广泛证明，而间接传播仅有附带证据支持，例如病毒在无生命表面上的持久性和其他类似病毒的数据。本系统综述旨在估计SARS-CoV-2在无生命表面上的患病率，根据表面特征识别风险水平。数据来自从两个数据库（PubMed和Embase）收集的已发表论文中的研究，最后一次搜索是在2020年9月1日。包含的研究必须是英文论文，不得不处理冠状病毒，不得不考虑在真实环境中无生命的表面。根据我们对被调查表面可能被SARS-CoV-2污染的风险的评估，对研究进行了编码。进行了meta分析和meta回归，以量化病毒RNA的流行程度，并确定驱动研究差异的重要因素。在40篇检索论文中，有39篇报告了在医疗机构中进行的关于病毒RNA流行率的研究，五项研究还通过细胞培养进行了分析，六项研究测试了分离病毒的生存能力。SARS-CoV-2RNA的总体流行率很高，中低风险表面为0.22（CI95[0.152-0.296]），0.04（CI95[0.007-0.090]），和0.00（CI95[0.00-0.019]），分别。暴露于病毒来源（患者）的持续时间表面是解释患病率差异的主要因素。
