PDF(Sci-hub)
Abstract：
Introduction: The apolipoprotein E ɛ4-allele (APOE-ɛ4) increases the risk not only for Alzheimer\'s disease (AD) but also for Parkinson\'s disease dementia and dementia with Lewy bodies (collectively, Lewy body dementia [LBD]). Hippocampal volume is an important neuroimaging biomarker for AD and LBD, although its association with APOE-ɛ4 is inconsistently reported. We investigated the association of APOE-ε4 with hippocampal atrophy quantified using magnetic resonance imaging in AD and LBD.Areas covered: Databases were searched for volumetric and voxel-based morphometric studies published up until December 31st, 2020. Thirty-nine studies (25 cross-sectional, 14 longitudinal) were included. We observed that (1) APOE-ε4 was associated with greater rate of hippocampal atrophy in longitudinal studies in AD and in those who progressed from mild cognitive impairment to AD, (2) association of APOE-ε4 with hippocampal atrophy in cross-sectional studies was inconsistent, (3) APOE-ɛ4 may influence hippocampal atrophy in dementia with Lewy bodies, although longitudinal investigations are needed. We comprehensively discussed methodological aspects, APOE-based therapeutic approaches, and the association of APOE-ε4 with hippocampal sub-regions and cognitive performance.Expert opinion: The role of APOE-ɛ4 in modulating hippocampal phenotypes may be further clarified through more homogenous, well-powered, and pathology-proven, longitudinal investigations. Understanding the underlying mechanisms will facilitate the development of prevention strategies targeting APOE-ɛ4.
摘要：
简介：载脂蛋白E4-等位基因（APOE-4）不仅增加了阿尔茨海默病（AD）的风险，而且增加了帕金森病痴呆和路易体痴呆（统称，路易体痴呆[LBD])。海马体积是AD和LBD的重要神经影像学指标,尽管它与APOE-º4的关联报道不一致。我们在AD和LBD中使用磁共振成像研究了APOE-ε4与海马萎缩的关系。涵盖的领域：在数据库中搜索了直到12月31日发表的基于体积和体素的形态计量学研究，2020年。39项研究(25项横断面研究，包括14个纵向)。我们观察到（1）在AD的纵向研究和从轻度认知障碍发展为AD的患者中，APOE-ε4与海马萎缩的发生率更高相关。(2)横断面研究中APOE-ε4与海马萎缩的相关性不一致,(3)APOE-4可能影响路易体痴呆患者海马萎缩,虽然需要纵向调查。我们全面讨论了方法论方面，基于APOE的治疗方法，APOE-ε4与海马亚区和认知能力的关系。专家意见：APOE-13C4在调节海马表型中的作用可能通过更同质，动力很好,病理证实，纵向调查。了解潜在的机制将有助于制定针对APOE-13C的预防策略。
